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New Advances in Germ Cell Research

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 20 May 2025 | Viewed by 1017

Special Issue Editor


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Guest Editor
Department of Medical Research, MacKay Memorial Hospital, Tamsui District, New Taipei 251, Taiwan
Interests: spermatogenesis; sperm capacitatio; cumulus cells

Special Issue Information

Dear Colleagues,

Germ cell research is a crucial topic in biology and medicine, including the study of gametes such as sperm and eggs. These studies involve not only animal models but also human reproductive cells. For example, researchers can explore the process of sperm development from genesis to maturation and the mechanisms of capacitation and fertilization in the female reproductive tract. Furthermore, scientists are working on identifying biomarker molecules in sperm that may help predict fertilization, miscarriage, or live birth.

Oocyte competence is another important research direction. Cumulus cells play a critical role in the oocyte maturation process, and researchers are investigating the relationship between cumulus cell gene expression and oocyte quality and searching for gene biomarkers associated with cumulus cell and oocyte maturation.

Overall, germ cell research covers the entire process from gamete development and maturation to fertilization, as well as the related molecular mechanisms and biomarkers. These studies not only contribute to deepening our understanding of reproductive biology but may also provide new insights and tools for diagnosing and treating infertility. Therefore, researchers are encouraged to conduct in-depth explorations in this field and share their latest findings.

Dr. Sheng-Hsiang Li
Guest Editor

Manuscript Submission Information

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Keywords

  • spermatogenesis
  • sperm capacitation
  • oogenesis
  • oocyte maturation
  • cumulus cells
  • fertilization
  • gene expression
  • biomarkers
  • exosomes
  • infertility

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Published Papers (1 paper)

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Research

11 pages, 3320 KiB  
Article
Cyclic AMP Rescue of Motility in Sperm Devoid of Soluble Adenylyl Cyclase
by Sylvia Ayoub, Natalia del R. Rivera Sanchez, Justine Fischoeder, Melanie Balbach, Lonny R. Levin, Jochen Buck and Carla Ritagliati
Int. J. Mol. Sci. 2025, 26(4), 1489; https://doi.org/10.3390/ijms26041489 - 11 Feb 2025
Viewed by 632
Abstract
The second messenger cAMP plays multiple critical roles in the control of sperm functions essential for male fertility, including motility. The enzyme soluble adenylyl cyclase (sAC; ADCY10) was shown genetically and pharmacologically to be the essential source of cAMP mediating many of these [...] Read more.
The second messenger cAMP plays multiple critical roles in the control of sperm functions essential for male fertility, including motility. The enzyme soluble adenylyl cyclase (sAC; ADCY10) was shown genetically and pharmacologically to be the essential source of cAMP mediating many of these functions. Male mice and men with genetic deletions of sAC are infertile, and their sperm are progressively immotile. Pharmacologically, delivery of potent and specific sAC inhibitors to male mice renders them temporarily infertile, and their sperm are similarly immotile. Here, we show that males from a second, independently derived mouse sAC knockout line are also infertile with progressively immotile sperm. We use these mouse models to determine optimal conditions for pharmacologically elevating intracellular cAMP to rescue the sAC null motility defect. We show that cell-permeable cAMP analogs, but not forskolin, rescue the motility defects of sAC deficient sperm, and we demonstrate that 8Br-cAMP is an efficient cAMP analog to rescue motility. Full article
(This article belongs to the Special Issue New Advances in Germ Cell Research)
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