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Recent Advances in Alzheimer’s Disease—2nd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: 31 October 2024 | Viewed by 424

Special Issue Editor


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Guest Editor
Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, 413 45 Gothenburg, Sweden
Interests: Alzheimer’s disease; microglia; zebrafish; neuronal networks
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder and the most common form of dementia in the elderly, manifesting as a chronic deterioration in cognition, primarily in memory, resulting from neuronal loss in specific regions of the brain. Genetics and pathology suggest that beta-amyloid build-up is the key process in the disease.

The hallmark features of AD include plaques composed of beta-amyloid and neurofibrillary tangles of tau protein. However, despite more than a century of research, the cause of AD remains inconclusive. The role of beta-amyloid and tau is under investigation, and other causes of AD are currently under consideration.

The scope of this Special Issue is to explore the different approaches research groups have used to close knowledge gaps surrounding AD pathogenesis. Authors are invited to submit original research or review articles linking molecular studies to new therapeutic avenues or prevention strategies for AD.

Dr. Petronella Kettunen
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Alzheimer’s disease
  • dementia
  • neurodegeneration
  • neuroinflammation
  • tauopathies
  • amyloid beta
  • biomarker discovery
  • microglia

Published Papers (1 paper)

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Review

20 pages, 828 KiB  
Review
From Inhalation to Neurodegeneration: Air Pollution as a Modifiable Risk Factor for Alzheimer’s Disease
by Jordi Olloquequi, Roberto Díaz-Peña, Ester Verdaguer, Miren Ettcheto, Carme Auladell and Antoni Camins
Int. J. Mol. Sci. 2024, 25(13), 6928; https://doi.org/10.3390/ijms25136928 - 25 Jun 2024
Viewed by 269
Abstract
Air pollution, a growing concern for public health, has been linked to various respiratory and cardiovascular diseases. Emerging evidence also suggests a link between exposure to air pollutants and neurodegenerative diseases, particularly Alzheimer’s disease (AD). This review explores the composition and sources of [...] Read more.
Air pollution, a growing concern for public health, has been linked to various respiratory and cardiovascular diseases. Emerging evidence also suggests a link between exposure to air pollutants and neurodegenerative diseases, particularly Alzheimer’s disease (AD). This review explores the composition and sources of air pollutants, including particulate matter, gases, persistent organic pollutants, and heavy metals. The pathophysiology of AD is briefly discussed, highlighting the role of beta-amyloid plaques, neurofibrillary tangles, and genetic factors. This article also examines how air pollutants reach the brain and exert their detrimental effects, delving into the neurotoxicity of air pollutants. The molecular mechanisms linking air pollution to neurodegeneration are explored in detail, focusing on oxidative stress, neuroinflammation, and protein aggregation. Preclinical studies, including in vitro experiments and animal models, provide evidence for the direct effects of pollutants on neuronal cells, glial cells, and the blood–brain barrier. Epidemiological studies have reported associations between exposure to air pollution and an increased risk of AD and cognitive decline. The growing body of evidence supporting air pollution as a modifiable risk factor for AD underscores the importance of considering environmental factors in the etiology and progression of neurodegenerative diseases, in the face of worsening global air quality. Full article
(This article belongs to the Special Issue Recent Advances in Alzheimer’s Disease—2nd Edition)
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