Molecular Targets in Preventing Pancreatic Cancer Progression
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 6948
Special Issue Editor
Special Issue Information
Dear Colleagues,
Pancreatic cancer is the seventh leading cause of cancer mortality in the world and the third leading cause in the USA. The five-year survival rate for pancreatic cancer is 9%, which is the lowest of all cancers. In addition, it is typically diagnosed at an advanced stage with a very poor prognosis. The survival rate at the early stage of diagnosis is also under 31%. Majority of the pancreatic cancers are exocrine cancers. Advances in next-generation sequencing have revealed the very heterogeneous nature of pancreatic cancer, which develops resistance to conventional chemotherapy and radiotherapy. Another key component of chemotherapy resistance is the desmoplasia of the tumor microenvironment in pancreatic ductal adenoma (PDAC). Understanding the molecular details of PDAC is important to an effective treatment intervention. Pancreatic organoids and 3D culture studies have made significant contributions to the advancement of research into the mechanism and development of drugs in pancreatic cancer. Recent progress in targeted drug delivery is an important tool to help prevent PDAC's progression. Exosome-based diagnosis also contributes greatly to early detection efforts.
For this special issue, the research articles, methods and reviews on molecular mechanism of pancreatic cancer, pancreatic organoids, exosomes, genetical approaches, in vitro, and in vivo on pancreatic cancer are invited. Besides, we’d like to gratefully acknowledge Dr. Anil Mathew Tharappel’s support in setting up, promoting, and developing this Special Issue.
Dr. Sijo Mathew
Guest Editor
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Keywords
- pancreatic cancer
- molecular markers
- pancreatic ductal adenocarcinoma
- organoids
- exosomes
- drug delivery
- diagnosis
- desmoplasia
- 3D culture
- integrin
- tumor microenvironment
- hypoxia
- PDX models
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