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Effects of Polyphenols on Cardiac Mitochondrial Function: Possible Implications in the Diabetic Heart

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (31 August 2020) | Viewed by 9712

Special Issue Editors

Prof. Donatella Stilli

E-Mail Website
Guest Editor
Dept of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parma, Italy
Interests: cardiomyocyte mechanics and calcium dynamics; cardiac electrophysiology; cardioprotective role and mechanisms of action of natural or synthetic chemical species, in experimental models of diabetic cardiomyopathy
Prof. Federica Rizzi

E-Mail Website
Guest Editor
Dept of Medicine and Surgery, University of Parma, Parma, Italy
Interests: molecular mechanisms of action of green tea catechins; cell signaling and metabolism in normal and pathological conditions

Special Issue Information

Dear Colleagues,

Mitochondrial dysfunction is a key feature of diabetic myocardium progressively resulting in altered cardiomyocyte electromechanical properties, in both type-1 and type-2 diabetes. Thus, maintenance of mitochondrial integrity and dynamics, and reduction of ROS production are promising targets for counteracting the occurrence of the diabetic cardiomyopathy phenotype. In this context, a great interest has been devoted to different polyphenols, antioxidant compounds that can modulate mitochondrial function directly, by ROS scavenging, or indirectly, by affecting signals, from or to mitochondria, which control the expression or the activity of specific enzymes. Although substantial advancement was made in this field, several questions remain unanswered and more investigations are needed to better define the mechanisms of action of these compounds. This knowledge will open the way for the pharmacological development of new more powerful molecules, with optimized pharmacokinetic properties, capable of preventing the functional remodeling of the diabetic heart.

In this Special Issue, we would like to invite original articles and review that focus on better understanding the mechanisms underlying the action of natural polyphenols or analogous synthetic compounds on mitochondrial function, in the diabetic heart.

Prof. Donatella Stilli
Prof. Federica Rizzi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Cardiomyopathy
  • Diabetes
  • Mitochondrial function
  • Cardiomyocyte respiration
  • Polyphenols
  • Catechins
  • Resveratrol
  • Cardiomyocyte mechanics
  • Cardiac electrophysiology
  • SERCA2 activity

Published Papers (2 papers)

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Review

24 pages, 1438 KiB  
Review
Mitochondrial Dysfunction in Diabetic Cardiomyopathy: The Possible Therapeutic Roles of Phenolic Acids
by Fatin Farhana Jubaidi, Satirah Zainalabidin, Vanitha Mariappan and Siti Balkis Budin
Int. J. Mol. Sci. 2020, 21(17), 6043; https://doi.org/10.3390/ijms21176043 - 22 Aug 2020
Cited by 34 | Viewed by 4474
Abstract
As the powerhouse of the cells, mitochondria play a very important role in ensuring that cells continue to function. Mitochondrial dysfunction is one of the main factors contributing to the development of cardiomyopathy in diabetes mellitus. In early development of diabetic cardiomyopathy (DCM), [...] Read more.
As the powerhouse of the cells, mitochondria play a very important role in ensuring that cells continue to function. Mitochondrial dysfunction is one of the main factors contributing to the development of cardiomyopathy in diabetes mellitus. In early development of diabetic cardiomyopathy (DCM), patients present with myocardial fibrosis, dysfunctional remodeling and diastolic dysfunction, which later develop into systolic dysfunction and eventually heart failure. Cardiac mitochondrial dysfunction has been implicated in the development and progression of DCM. Thus, it is important to develop novel therapeutics in order to prevent the progression of DCM, especially by targeting mitochondrial dysfunction. To date, a number of studies have reported the potential of phenolic acids in exerting the cardioprotective effect by combating mitochondrial dysfunction, implicating its potential to be adopted in DCM therapies. Therefore, the aim of this review is to provide a concise overview of mitochondrial dysfunction in the development of DCM and the potential role of phenolic acids in combating cardiac mitochondrial dysfunction. Such information can be used for future development of phenolic acids as means of treating DCM by alleviating the cardiac mitochondrial dysfunction. Full article
(This article belongs to the Special Issue Effects of Polyphenols on Cardiac Mitochondrial Function: Possible Implications in the Diabetic Heart)
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12 pages, 1658 KiB  
Review
The Mitochondria: A Target of Polyphenols in the Treatment of Diabetic Cardiomyopathy
by Humna Bhagani, Suzanne A. Nasser, Ali Dakroub, Ahmed F. El-Yazbi, Assaad A. Eid, Firas Kobeissy, Gianfranco Pintus and Ali H. Eid
Int. J. Mol. Sci. 2020, 21(14), 4962; https://doi.org/10.3390/ijms21144962 - 14 Jul 2020
Cited by 32 | Viewed by 4926
Abstract
Diabetic cardiomyopathy (DCM) is a constellation of symptoms consisting of ventricular dysfunction and cardiomyocyte disarray in the presence of diabetes. The exact cause of this type of cardiomyopathy is still unknown; however, several processes involving the mitochondria, such as lipid and glucose metabolism, [...] Read more.
Diabetic cardiomyopathy (DCM) is a constellation of symptoms consisting of ventricular dysfunction and cardiomyocyte disarray in the presence of diabetes. The exact cause of this type of cardiomyopathy is still unknown; however, several processes involving the mitochondria, such as lipid and glucose metabolism, reactive oxygen species (ROS) production, apoptosis, autophagy and mitochondrial biogenesis have been implicated. In addition, polyphenols have been shown to improve the progression of diabetes. In this review, we discuss some of the mechanisms by which polyphenols, particularly resveratrol, play a role in slowing the progression of DCM. The most important intermediates by which polyphenols exert their protective effect include Bcl-2, UCP2, SIRT-1, AMPK and JNK1. Bcl-2 acts to attenuate apoptosis, UCP2 decreases oxidative stress, SIRT-1 increases mitochondrial biogenesis and decreases oxidative stress, AMPK increases autophagy, and JNK1 decreases apoptosis and increases autophagy. Our dissection of these molecular players aims to provide potential therapeutic targets for the treatment of DCM. Full article
(This article belongs to the Special Issue Effects of Polyphenols on Cardiac Mitochondrial Function: Possible Implications in the Diabetic Heart)
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