Protein Solubility and Aggregation
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biophysics".
Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 11817
Special Issue Editor
Special Issue Information
Dear Colleagues,
Protein solubility and aggregation is a serious problem for protein sciences, pharmaceutical applications, and human health. The level of protein solubility ranges from almost completely insoluble to hundreds of milligrams per milliliter. Amino acids at the surface of a protein may determine the solubility. The structural stability of a protein may be important for solubility. Even a single amino acid mutation may change the solubility of a protein dramatically. External factors such as pH, ionic strength, temperature, mechanical stress, small molecules, etc. also affect the protein solubility. Low solubility would decrease the efficiency of the protein purification and the production yield of protein drugs. Protein aggregation, resulting from protein misfolding, leads to many diseases such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and prion disease, to name but a few.
We invite researchers to contribute original and review articles regarding the protein solubility and aggregation. Potential topics include, but are not limited to the following:
- Molecular mechanism of protein aggregation
- Determinants of protein solubility
- Small molecule solubility enhancer
- Chaperone protein
- Database of protein solubility
- Prediction of protein solubility
- Protein aggregation disease
- Protein misfolding
- Therapeutics of protein aggregation
Prof. Dr. Han S. Choe
Guest Editor
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