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State-of-the-Art Molecular Mechanisms of Pulmonary Pathology in Italy
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State-of-the-Art Molecular Mechanisms of Pulmonary Pathology in Italy

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (30 September 2022) | Viewed by 2880

Special Issue Editor

Prof. Patrizia Russo

E-Mail Website
Collection Editor
1. Department of Human Sciences and Quality, Life Promotion San Raffaele University, Via di Val Cannuta 247, 00166 Rome, Italy 2. MEBIC Consortium, San Raffaele University, 00166 Rome, Italy
Interests: DNA damage; Nicotine and nicotinic receptor; COVID19; respiratory disease; Toeque teno virus; History of Medicine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Topical Collection aims to provide an up-to-date and comprehensive view of the state of the art of Pulmonary Pathology in Italy.

Based on long-term traditions of fundamental science in Italy, we would like to provide a comprehensive insight into the state of the art of research activities in the country regarding molecular mechanisms of pathogenesis and treatment in pulmonary diseases. All kinds of articles are welcome, including contributions about original investigations in the field as well as reviews. The covered topics of interest include but are not limited to the following:

  • Lung cancer
  • Lung microbiota
  • Lung diseases
  • Lung injury and repair
  • Lung development
  • COPD
  • Pulmonology
  • Lung cancer biomarkers
  • Lung adenocarcinoma
  • Asthma
  • Pulmonary fibrosis
  • Lung infection
  • Bronchiectasis
  • Respiratory diseases
  • Pneumonia
  • Cystic fibrosis

Dr. Patrizia Russo
Collection Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (2 papers)

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15 pages, 1347 KiB  
Article
Effect of Cigarette Smoking on Clinical and Molecular Endpoints in COPD Patients
by Patrizia Russo, Francesca Milani, Antonio De Iure, Stefania Proietti, Dolores Limongi, Carla Prezioso, Paola Checconi, Vincenzo Zagà, Federica Novazzi, Fabrizio Maggi, Guido Antonelli and Stefano Bonassi
Int. J. Mol. Sci. 2024, 25(11), 5834; https://doi.org/10.3390/ijms25115834 - 27 May 2024
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Abstract
Cigarette smoking is a primary contributor to mortality risks and is associated with various diseases. Among these, COPD represents a significant contributor to global mortality and disability. The objective of this study is to investigate the effect of smoking on a selected battery [...] Read more.
Cigarette smoking is a primary contributor to mortality risks and is associated with various diseases. Among these, COPD represents a significant contributor to global mortality and disability. The objective of this study is to investigate the effect of smoking on a selected battery of variables, with an emphasis on DNA damage. A total of 87 elderly patients diagnosed with COPD, divided into three groups based on their smoking history (current, former, never-smokers), were evaluated using a cross-sectional approach. Clinical features including mortality and inflammatory/oxidative parameters (Lymphocytes/Monocytes, Neutrophils/Lymphocytes, Platelets/Lymphocytes ratio), SII, MDA, 8-Oxo-dG, and IL6 (ELISA assay), as well as DNA damage (comet assay), were investigated. Virus infection, i.e., influenza A virus subtype H1N1, JC polyomavirus (JCPyV), BK polyomavirus (BKPyV), and Torquetenovirus (TTV), was also tested. Current smokers exhibit higher levels of comorbidity (CIRS; p < 0.001), Platelets/Lymphocytes ratio (p < 0.001), systemic immune inflammation (p < 0.05), and DNA damage (p < 0.001). Former smokers also showed higher values for parameters associated with oxidative damage and showed a much lower probability of surviving over 5 years compared to never- and current smokers (p < 0.0017). This study showed a clear interaction between events which are relevant to the oxidative pathway and cigarette smoking. A category of particular interest is represented by former smokers, especially for lower survival, possibly due to the presence of more health problems. Our findings raise also the attention to other parameters which are significantly affected by smoking and are useful to monitor COPD patients starting a program of pulmonary rehabilitation (DNA damage, inflammation parameters, and selected viral infections). Full article
(This article belongs to the Special Issue State-of-the-Art Molecular Mechanisms of Pulmonary Pathology in Italy)
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7 pages, 1130 KiB  
Case Report
Oligorecurrent Non-Small-Cell Lung Cancer Treated by Chemo-Radiation Followed by Immunotherapy and Intracranial Radiosurgery: A Case Report and Mini Review of Literature
by Alessio Bruni, Federica Bertolini, Elisa D’Angelo, Giorgia Guaitoli, Jessica Imbrescia, Anna Cappelli, Gabriele Guidi, Alessandro Stefani, Massimo Dominici and Frank Lohr
Int. J. Mol. Sci. 2023, 24(3), 1892; https://doi.org/10.3390/ijms24031892 - 18 Jan 2023
Viewed by 1872
Abstract
Locally advanced non-small-cell lung cancer still represents a “grey zone” in terms of the best treatment choice and optimal clinical outcomes. Indeed, most patients may be suitable to receive different treatments with similar outcomes such as chemo-radiotherapy (CHT-RT) followed by immunotherapy (IO) or [...] Read more.
Locally advanced non-small-cell lung cancer still represents a “grey zone” in terms of the best treatment choice and optimal clinical outcomes. Indeed, most patients may be suitable to receive different treatments with similar outcomes such as chemo-radiotherapy (CHT-RT) followed by immunotherapy (IO) or surgery followed by adjuvant local/systemic therapies. We report a clinical case of a patient submitted to primary thoracic surgery who developed a mediastinal nodal recurrence successfully treated by CHT-RT-IO. Subsequently, a single brain lesion was found to have been successfully treated by single fraction stereotactic ablative radiotherapy. The patient is still on follow-up and she is free from disease having a good quality of life. In this report, we also perform a mini review about the role of CHT-RT followed by IO in treating loco-regional relapse after surgery. The role of SABR after IO is also evaluated, finding that it is safe and well tolerated. More robust and larger clinical data are needed in this particular setting to better define the role of the combination of systemic and local treatments in the management of intrathoracic and intracranial relapse for patients already submitted to CHT-RT followed by immunotherapy. Full article
(This article belongs to the Special Issue State-of-the-Art Molecular Mechanisms of Pulmonary Pathology in Italy)
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