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Role of Exosomes in Intercellular Communication

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 20 December 2024 | Viewed by 1952

Special Issue Editor


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Guest Editor
Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH 44272, USA
Interests: diabetes and obesity-associated cardiovascular diseases; stem cell-based gene delivery; cell therapy after ischemic injury

Special Issue Information

Dear Colleagues,

Exosomes are nanosized extracellular vehicles that play an important role in intercellular communication. These small vesicles carry a cargo of bioactive molecules, which can be transferred between cells, influencing various physiological and pathological processes. The field of exosome research has seen significant progress in recent years, providing insights into their multifaceted functions in biology and medicine. This Special Issue of the International Journal of Molecular Sciences aims to explore the fundamental theoretical questions related to exosomes and their innovative applications in medicine.

Topics of interest include, but are not limited to:

  • Exosome biogenesis and secretion mechanisms.
  • Regulatory pathways and signaling cascades involving exosomes.
  • New methods for exosome isolation, characterization, and analysis.
  • High-resolution imaging and tracking of exosomes.
  • The role of exosomes in disease pathogenesis, such as cardiovascular diseases.
  • Therapeutic applications of exosomes (drug delivery, regenerative medicine, etc.).
  • Diagnostic potential of exosome biomarkers in various diseases.

Submission Guidelines: Researchers, scientists, and experts in the field are invited to submit their original research articles, reviews, and perspectives for consideration in this Special Issue. Manuscripts should comply with the journals guidelines, and all submissions will undergo a rigorous peer-review process to ensure the quality and relevance of the content.

Dr. Feng Dong
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • exosomes
  • intercellular communication
  • extracellular vehicles
  • small vesicles

Published Papers (1 paper)

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Review

28 pages, 2748 KiB  
Review
Exosomes: A New Hope for Angiogenesis-Mediated Bone Regeneration
by Martin Lange, Patrick Babczyk and Edda Tobiasch
Int. J. Mol. Sci. 2024, 25(10), 5204; https://doi.org/10.3390/ijms25105204 - 10 May 2024
Viewed by 1509
Abstract
Bone is a metabolically dynamic structure that is generally remodeled throughout the lifetime of an individual but often causes problems with increasing age. A key player for bone development and homeostasis, but also under pathological conditions, is the bone vasculature. This complex system [...] Read more.
Bone is a metabolically dynamic structure that is generally remodeled throughout the lifetime of an individual but often causes problems with increasing age. A key player for bone development and homeostasis, but also under pathological conditions, is the bone vasculature. This complex system of arteries, veins, and capillaries forms distinct structures where each subset of endothelial cells has important functions. Starting with the basic process of angiogenesis and bone-specific blood vessel formation, coupled with initial bone formation, the importance of different vascular structures is highlighted with respect to how these structures are maintained or changed during homeostasis, aging, and pathological conditions. After exemplifying the current knowledge on bone vasculature, this review will move on to exosomes, a novel hotspot of scientific research. Exosomes will be introduced starting from their discovery via current isolation procedures and state-of-the-art characterization to their role in bone vascular development, homeostasis, and bone regeneration and repair while summarizing the underlying signal transduction pathways. With respect to their role in these processes, especially mesenchymal stem cell-derived extracellular vesicles are of interest, which leads to a discussion on patented applications and an update on ongoing clinical trials. Taken together, this review provides an overview of bone vasculature and bone regeneration, with a major focus on how exosomes influence this intricate system, as they might be useful for therapeutic purposes in the near future. Full article
(This article belongs to the Special Issue Role of Exosomes in Intercellular Communication)
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