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Molecular Research on Retina 2.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (15 April 2024) | Viewed by 2767

Special Issue Editor


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Guest Editor
Department of Ophthalmology and Visual Science, University of Chicago Medical Center, Chicago, IL 60637, USA
Interests: age-related macular degeneration; diabetic retinopathy; central serous retinopathy; choroidal melanoma; retinoblastoma; retinal detachment; proliferative vitreoretinopathy; retinopathy of prematurity; posterior uveitis; inherited retinal diseases; macular hole; epiretinal membrane; retinal vein occlusion
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Special Issue Information

Dear Colleagues,

Recent advances in molecular techniques such as high-throughput and single-cell RNA sequencing, genetics, microbiomics, metabolomics, iPS cells, in combination with advanced retina imaging, Big Data, and advanced bioinformatics analysis-network medicine have introduced powerful new tools for novel frontiers in retinal research. These exciting new cutting-edge technologies were not available to most of us just a decade ago, but these new tools will lead to a new era of elucidating the molecular mechanisms of retinal disorders and discovery of new targets and therapeutic strategies. The purpose of this Special Issue is to highlight recent and novel frontiers in retinal research. In this Special Issue, we welcome original research or review articles on novel molecular biology methods and new techniques to verify the pathogenic mechanism of retinal disorders.

The relevant retinal diseases include age-related macular degeneration, diabetic retinopathy, central serous retinopathy, choroidal melanoma, retinoblastoma, retinal detachment, proliferative vitreoretinopathy, retinopathy of prematurity, posterior uveitis, inherited retinal diseases, macular hole, epiretinal membrane, and retinal vein occlusion.

Dr. Dimitra Skondra
Guest Editor

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Keywords

  • retina
  • nutrition
  • genetics
  • high-throughput RNA/DNA sequencing
  • stem cells
  • metabolomics
  • microbiome
  • transcriptomics
  • meta-transcriptomics
  • proteomics
  • epigenetics
  • single-cell
  • multi-omics
  • bioinformatics
  • network medicine
  • advanced retinal imaging
  • biotechnology
  • retina organoids
  • iPSC
  • network medicine
  • computational analysis

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Published Papers (1 paper)

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Review

30 pages, 1198 KiB  
Review
Establishing Functional Retina in a Dish: Progress and Promises of Induced Pluripotent Stem Cell-Based Retinal Neuron Differentiation
by Nonthaphat Kent Wong, Shea Ping Yip and Chien-Ling Huang
Int. J. Mol. Sci. 2023, 24(17), 13652; https://doi.org/10.3390/ijms241713652 - 4 Sep 2023
Viewed by 2293
Abstract
The human eye plays a critical role in vision perception, but various retinal degenerative diseases such as retinitis pigmentosa (RP), glaucoma, and age-related macular degeneration (AMD) can lead to vision loss or blindness. Although progress has been made in understanding retinal development and [...] Read more.
The human eye plays a critical role in vision perception, but various retinal degenerative diseases such as retinitis pigmentosa (RP), glaucoma, and age-related macular degeneration (AMD) can lead to vision loss or blindness. Although progress has been made in understanding retinal development and in clinical research, current treatments remain inadequate for curing or reversing these degenerative conditions. Animal models have limited relevance to humans, and obtaining human eye tissue samples is challenging due to ethical and legal considerations. Consequently, researchers have turned to stem cell-based approaches, specifically induced pluripotent stem cells (iPSCs), to generate distinct retinal cell populations and develop cell replacement therapies. iPSCs offer a novel platform for studying the key stages of human retinogenesis and disease-specific mechanisms. Stem cell technology has facilitated the production of diverse retinal cell types, including retinal ganglion cells (RGCs) and photoreceptors, and the development of retinal organoids has emerged as a valuable in vitro tool for investigating retinal neuron differentiation and modeling retinal diseases. This review focuses on the protocols, culture conditions, and techniques employed in differentiating retinal neurons from iPSCs. Furthermore, it emphasizes the significance of molecular and functional validation of the differentiated cells. Full article
(This article belongs to the Special Issue Molecular Research on Retina 2.0)
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