Sphingolipid Metabolism and Signaling: Role in Health and Diseases—2nd Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: 31 December 2024 | Viewed by 63
Special Issue Editor
Interests: sphingolipids; sphingosine-1-phosphate; ceramide; signaling; cancer; multiple sclerosis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Sphingolipids are a class of lipids that are highly expressed in eukaryotic cells. Sphingolipids are ubiquitous components of cell membranes as well as bioactive molecules involved in the control of cell fate in physiological and pathophysiological processes. Sphingolipid metabolism and signaling are crucial for the maintenance of physiological conditions, but, on the other hand, the dysregulation of sphingolipid metabolism, leading to altered sphingolipid patterns, is associated with different pathological conditions. Sphingolipid levels are regulated via the modulation of the metabolism of specific enzymes as well as that of the specific receptors or transporters involved in their transport within or outside cells; however, the exact molecular mechanisms mediated by sphingolipids with which to modulate cell homeostasis are still not completely understood. New knowledge on the metabolism and signaling of sphingolipids will help in finding therapeutic solutions in a variety of human diseases.
For this Special Issue, “Sphingolipid Metabolism and Signaling: Role in Health and Diseases—2nd Edition”, we welcome your contributions in the form of original research and review articles on all aspects of sphingolipids and their roles in physiological and pathophysiological processes.
Dr. Paola Giussani
Guest Editor
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Keywords
- sphingolipids
- sphingosine-1-phosphate
- ceramide
- glycosphingolipids
- sphingolipid-mediated signaling
- cancer
- neurodegenerative diseases
- inflammatory diseases
- diabetes
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