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Aging in Cardiovascular Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 20 July 2024 | Viewed by 485

Special Issue Editor


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Guest Editor
1. Institute of Pharmacology and Clinical Pharmacology, Faculty of Medicine Comenius University, Sasinkova 4, 81108 Bratislava, Slovakia
2. Institute of Normal and Pathological Physiology, Centre of Experimental Medicine, Slovak Academy of Sciences, Sienkiewiczova 1, 81371 Bratislava, Slovakia
Interests: experimental hypertension; endothelial dysfunction; vascular tone regulation; inflammation; aging
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Special Issue Information

Dear Colleagues,

Advances in cardiovascular research and medicine have led to a decrease in morbidity and mortality of cardiovascular diseases (CVD) and partially shifted cardiovascular complications to older population. However, there is not enough attention given to the relation of CVD and aging. Hypertension still represents the silent killer among CVD and remains underdiagnosed in more than one third of population. Sedentary lifestyle and unhealthy dietary habits led to development of atherosclerosis in older population further worsening CVD. This special issue focuses on the molecular mechanisms underlying the development of CVD during aging and factors involved in improvement of quality of life. Outcomes of experimental studies and clinical trials as well as case reports that disclose molecular pathophysiological mechanisms, new molecular factors, drug interactions or possible adverse drug reactions in therapy of CVD and aging are welcome.

Dr. Silvia Liskova
Guest Editor

Manuscript Submission Information

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Keywords

  • aging
  • hypertension
  • endothelium
  • vascular smooth muscle cells
  • pulmonary hypertension
  • atherosclerosis
  • hyperlipidemia

Published Papers (1 paper)

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Review

12 pages, 870 KiB  
Review
Ca2+-Dependent Cl Channels in Vascular Tone Regulation during Aging
by Miriam Petrova, Monika Lassanova, Jana Tisonova and Silvia Liskova
Int. J. Mol. Sci. 2024, 25(10), 5093; https://doi.org/10.3390/ijms25105093 - 7 May 2024
Viewed by 191
Abstract
Identifying alterations caused by aging could be an important tool for improving the diagnosis of cardiovascular diseases. Changes in vascular tone regulation involve various mechanisms, like NO synthase activity, activity of the sympathetic nervous system, production of prostaglandin, endothelium-dependent relaxing, and contracting factors, [...] Read more.
Identifying alterations caused by aging could be an important tool for improving the diagnosis of cardiovascular diseases. Changes in vascular tone regulation involve various mechanisms, like NO synthase activity, activity of the sympathetic nervous system, production of prostaglandin, endothelium-dependent relaxing, and contracting factors, etc. Surprisingly, Ca2+-dependent Cl channels (CaCCs) are involved in all alterations of the vascular tone regulation mentioned above. Furthermore, we discuss these mechanisms in the context of ontogenetic development and aging. The molecular and electrophysiological mechanisms of CaCCs activation on the cell membrane of the vascular smooth muscle cells (VSMC) and endothelium are explained, as well as the age-dependent changes that imply the activation or inhibition of CaCCs. In conclusion, due to the diverse intracellular concentration of chloride in VSMC and endothelial cells, the activation of CaCCs depends, in part, on intracellular Ca2+ concentration, and, in part, on voltage, leading to fine adjustments of vascular tone. The activation of CaCCs declines during ontogenetic development and aging. This decline in the activation of CaCCs involves a decrease in protein level, the impairment of Ca2+ influx, and probably other alterations in vascular tone regulation. Full article
(This article belongs to the Special Issue Aging in Cardiovascular Diseases)
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