Submit to IJMS Review for IJMS Propose a Special Issue

Journal Menu

Journal Browser

Biomarkers of Autoimmune Chronic Spontaneous Urticaria

Print Special Issue Flyer
Special Issue Editors
Special Issue Information
Keywords
Published Papers

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 7620

Share This Special Issue

Special Issue Editors

Prof. Dr. Elias Toubi

E-Mail Website
Guest Editor

The Proteomic and Clinical Flow Cytometry Unit, Bnai-Zion Medical Center, The Rappaport Faculty of Medicine, Technion, Haifa 31048, Israel
Interests: autoimmunity; regulatory mechanisms; chronic spontaneous urticaria

Prof. Dr. Zahava Vadasz

E-Mail Website
Guest Editor

Bnai Zion Medical Center, Haifa 3339419, Israel
Interests: immune-mediated-inflammation; semaphorins; regulatory molecules; chronic spontaneous urticaria

Special Issue Information

Dear Colleagues,

Biomarkers: An unmet need for the assessment of chronic spontaneous urticaria

Chronic spontaneous urticaria (CSU) is a devastating disease during which patients suffer from transient itchy wheals in association with episodes of angioedema, which are present in 40% of cases, or angioedema alone, in around 10% of cases. CSU is frequently a long-lasting disorder and is associated with co-morbidities such as fatigue, sleeplessness and anxiety, leading to an insufficient quality of life. Auto-reactive T cells and autoimmunity in general are primary factors in the pathogenesis of CSU. The response to treatment (both standard and omalizumab) is unpredictable in most cases, and the ability to predict this is important. Finally, patients frequently ask questions concerning how long the suffering will last, and whether it will come back at some stage once it has gone. The above questions require the usage of possible biomarkers aiming to predict one or more of the above raised issues. In this Special Issue, we aim to focus on biomarkers in the serum and skin of patients with CSU in an attempt to better define the pathogenesis, prognosis and response to treatment.

Prof. Dr. Elias Toubi
Prof. Dr. Zahava Vadasz
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

Chronic Spontaneous Urticaria (CSU)
autoimmunity
cytokines
biomarkers
chemokines

Published Papers (4 papers)

Download All Papers

Order results

Result details

Show export options Show export options

Select all

Export citation of selected articles as:

Research

Jump to: Review

11 pages, 2775 KiB

Open AccessArticle

Time Course of Priming Effect of TF Inducers on Synergistic TF Expression and Intra-Cellular Gap Formation of Human Vascular Endothelial Cells via the Extrinsic Coagulation Cascade

by Daiki Matsubara, Takuma Kunieda, Yuhki Yanase, Shunsuke Takahagi, Kazue Uchida, Tomoko Kawaguchi, Kaori Ishii, Akio Tanaka, Koichiro Ozawa and Michihiro Hide

Int. J. Mol. Sci. 2023, 24(15), 12388; https://doi.org/10.3390/ijms241512388 - 3 Aug 2023

Viewed by 753

Abstract

Chronic spontaneous urticaria (CSU) is characterized by daily recurring wheal and flare with itch for more than 6 weeks. The extrinsic coagulation system has been shown to be activated in correlation with CSU severity. We have reported that tissue factor (TF), a trigger of the extrinsic coagulation cascade, is synergistically expressed on vascular endothelial cells by simultaneous stimulation with TF inducers (TFI), followed by activation of the extrinsic coagulation cascade and hyper permeability in vitro. However, vascular endothelial cells are not likely to be simultaneously stimulated by multiple TFIs under physiological conditions. Therefore, in order to know whether sequential, rather than simultaneous, stimuli with interval may induce synergistic activation of TF, we investigated the time course of the priming effects of each TFI for synergistic TF expression in vascular endothelial cells (HUVECs). We stimulated HUVECs with a TFI (first stimulation) and then stimulated cells with another TFI at indicated time points (second stimulation) and detected TF expression and activity. The TF expression induced by simultaneous stimulation diminished in a few hours. However, both synergistic enhancement of TF expression and activation level of the coagulation cascade were detected even when the second stimulation was added 18 or 22 h after the first stimulation. Thus, the priming effect of TFI for synergistic TF expression may persist for a half day or longer. Full article

(This article belongs to the Special Issue Biomarkers of Autoimmune Chronic Spontaneous Urticaria)

► Show Figures

Figure 1

7 pages, 784 KiB

Open AccessCommunication

Thyroid Autoimmunity in CSU: A Potential Marker of Omalizumab Response?

by Riccardo Asero, Silvia Mariel Ferrucci, Paolo Calzari, Dario Consonni and Massimo Cugno

Int. J. Mol. Sci. 2023, 24(8), 7491; https://doi.org/10.3390/ijms24087491 - 19 Apr 2023

Cited by 7 | Viewed by 1387

Abstract

The response of severe chronic spontaneous urticaria (CSU) to omalizumab largely depends on the autoimmune or autoallergic endotype of the disease. Whether thyroid autoimmunity may predict omalizumab response along with total IgE in CSU is still unclear. Three hundred and eighty-five patients (M/F 123/262; mean age 49.5 years; range 12–87 years) with severe CSU were studied. Total IgE levels and thyroid autoimmunity (levels of anti-thyroid peroxidase [TPO] IgG) were measured before omalizumab treatment. Based on the clinical response, patients were divided into early (ER), late (LR), partial (PR) and non (NR) responders to omalizumab. Thyroid autoimmunity was detected in 92/385 (24%) patients. Altogether, 52%, 22%, 16% and 10% of patients were ER, LR, PR and NR to omalizumab, respectively. Response to omalizumab was not associated with thyroid autoimmunity (p = 0.77). Conversely, we found a strongly positive association between IgE levels and omalizumab response (p < 0.0001); this association was largely driven by early response (OR = 5.46; 95% CI: 2.23–13.3). Moreover, the predicted probabilities of early response strongly increased with increasing IgE levels. Thyroid autoimmunity alone cannot be used as a clinical predictor of omalizumab response. Total IgE levels remain the only and most reliable prognostic marker for omalizumab response in patients with severe CSU. Full article

(This article belongs to the Special Issue Biomarkers of Autoimmune Chronic Spontaneous Urticaria)

► Show Figures

Figure 1

Review

Jump to: Research

14 pages, 321 KiB

Open AccessReview

Biomarkers for Monitoring Treatment Response of Omalizumab in Patients with Chronic Urticaria

by Nadja Højgaard Pedersen, Jennifer Astrup Sørensen, Misbah Noshela Ghazanfar, Ditte Georgina Zhang, Christian Vestergaard and Simon Francis Thomsen

Int. J. Mol. Sci. 2023, 24(14), 11328; https://doi.org/10.3390/ijms241411328 - 11 Jul 2023

Cited by 5 | Viewed by 2201

Abstract

Chronic urticaria (CU) is a debilitating skin disease affecting around 1% of the population. CU can be subdivided into chronic spontaneous urticaria (CSU) and chronic inducible urticaria (CIndU). Different pathophysiological mechanisms have been proposed to play a role in the development of CU, and these are also being investigated as potential biomarkers in the diagnosis and management of the disease. As of now the only assessment tools available for treatment response are patient reported outcomes (PROs). Although these tools are both validated and widely used, they leave a desire for more objective measurements. A biomarker is a broad subcategory of observations that can be used as an accurate, reproducible, and objective indicator of clinically relevant outcomes. This could be normal biological or pathogenic processes, or a response to an intervention or exposure, e.g., treatment response. Herein we provide an overview of biomarkers for CU, with a focus on prognostic biomarkers for treatment response to omalizumab, thereby potentially aiding physicians in personalizing treatments. Full article

(This article belongs to the Special Issue Biomarkers of Autoimmune Chronic Spontaneous Urticaria)

11 pages, 1196 KiB

Open AccessReview

Basophil Characteristics as a Marker of the Pathogenesis of Chronic Spontaneous Urticaria in Relation to the Coagulation and Complement Systems

by Yuhki Yanase, Daiki Matsubara, Shunsuke Takahagi, Akio Tanaka, Koichiro Ozawa and Michihiro Hide

Int. J. Mol. Sci. 2023, 24(12), 10320; https://doi.org/10.3390/ijms241210320 - 19 Jun 2023

Cited by 8 | Viewed by 2648

Abstract

Chronic spontaneous urticaria (CSU) is a common skin disorder characterized by daily or almost daily recurring skin edema and flare with itch and pruritus anywhere on the body for more than 6 weeks. Although basophil- and mast cell-released inflammatory mediators, such as histamine, play important roles in the pathogenesis of CSU, the detailed underlying mechanism is not clear. Since several auto-antibodies, IgGs which recognize IgE or the high-affinity IgE receptor (FcεRI) and IgEs against other self-antigens, are detected in CSU patients, they are considered to activate both mast cells in the skin and basophils circulating in the blood. In addition, we and other groups demonstrated that the coagulation and complement system also contribute to the development of urticaria. Here, we summarized the behaviors, markers and targets of basophils in relation to the coagulation–complement system, and for the treatment of CSU. Full article

(This article belongs to the Special Issue Biomarkers of Autoimmune Chronic Spontaneous Urticaria)

► Show Figures

Journal Menu

Journal Browser

Biomarkers of Autoimmune Chronic Spontaneous Urticaria

Share This Special Issue

Special Issue Editors

Special Issue Information

Keywords

Published Papers (4 papers)

Research

Review

Further Information

Guidelines

MDPI Initiatives

Follow MDPI