ijms-logo

Journal Browser

Journal Browser

Gene Expression Regulatory Mechanisms in the Adrenal Gland

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".

Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 2970

Special Issue Editors


E-Mail Website
Guest Editor
Department of Histology and Embryology, Poznan University of Medical Sciences, Swiecickiego 6 Street, 60-781 Poznan, Poland
Interests: adrenal gland; gene expression; regulatory mechanisms

E-Mail Website
Guest Editor
Department of Histology and Embryology, Poznan University of Medical Sciences, Swiecickiego 6 Street, 60-781 Poznan, Poland
Interests: fat; liver; cirrhosis; ulcerative colitis; liver diseases; biliary tract diseases; liver cirrhosis; liver diseases and immunology; liver failure; inflammatory bowel disease

Special Issue Information

Dear Colleagues,

Adrenal glands are endocrine organs that are very important for the proper functioning of a living organism. The characteristic structure of the gland influences its functions in the body. It is now known that adrenal glands can differ in structure between different species or individuals of the same species but of different sexes. Adrenals interact with the hypothalamus and pituitary gland in the specific axis, controlling the secretion of neuropeptides involved in food intake and energy expenditure, and thus playing a significant role in maintaining homeostasis in the body. In addition, there is cooperation between cells within the gland itself, where a specific microenvironment exists, and the paracrine pathway regulates the synthesis of steroid hormones through neuropeptides secreted by medullary cells. Due to their crucial function, adrenal glands are continuously studied.

The development of molecular techniques allows for a precise understanding of the mechanisms responsible for the involvement of the adrenal glands in the proper functioning of the body and, over the years, many results have emerged that shed light on the role adrenal glands play in homeostatic mechanisms, as well as how various factors influence the growth, differentiation, and functions of adrenal cells, both under physiological and pathological conditions. Particularly, techniques that investigate the mechanisms of gene expression regulation are of great importance. However, not everything has been fully understood yet; therefore, we invite scientists interested in clarifying this topic to submit their findings for the next Special Issue.

Dr. Marianna Tyczewska
Dr. Małgorzata Blatkiewicz
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • adrenal gland
  • gene expression
  • molecular analysis
  • regulation of transcription
  • regulation of translation

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

22 pages, 9106 KiB  
Article
Transcriptome Profile of the Rat Adrenal Gland: Parenchymal and Interstitial Cells
by Marianna Tyczewska, Patrycja Sujka-Kordowska, Marta Szyszka, Karol Jopek, Małgorzata Blatkiewicz, Ludwik K. Malendowicz and Marcin Rucinski
Int. J. Mol. Sci. 2023, 24(11), 9159; https://doi.org/10.3390/ijms24119159 - 23 May 2023
Cited by 1 | Viewed by 2697
Abstract
The homeostasis of the adrenal gland plays a decisive role in its proper functioning, both in non-stressful conditions and under the influence of various types of stress. This consists of interactions between all types of cells that make up the organ, including parenchymal [...] Read more.
The homeostasis of the adrenal gland plays a decisive role in its proper functioning, both in non-stressful conditions and under the influence of various types of stress. This consists of interactions between all types of cells that make up the organ, including parenchymal and interstitial cells. The amount of available information on this subject in the rat adrenal glands under non-stressful conditions is insufficient; the aim of the research was to determine the expression of marker genes for rat adrenal cells depending on their location. The material for the study consisted of adrenal glands taken from intact adult male rats that were separated into appropriate zones. Transcriptome analysis by means of Affymetrix® Rat Gene 2.1 ST Array was used in the study, followed by real-time PCR validation. Expression analysis of interstitial cell marker genes revealed both the amount of expression of these genes and the zone in which they were expressed. The expression of marker genes for fibroblasts was particularly high in the cells of the ZG zone, while the highest expression of specific macrophage genes was observed in the adrenal medulla. The results of this study, especially with regard to interstitial cells, provide a so far undescribed model of marker gene expression of various cells, both in the cortex and medulla of the sexually mature rat adrenal gland. The interdependence between parenchymal and interstitial cells creates a specific microenvironment that is highly heterogeneous within the gland with respect to some of the interstitial cells. This phenomenon most likely depends on the interaction with the differentiated parenchymal cells of the cortex, as well as the medulla of the gland. Full article
(This article belongs to the Special Issue Gene Expression Regulatory Mechanisms in the Adrenal Gland)
Show Figures

Figure 1

Back to TopTop