Sirtuins and Epigenetics in Aging and Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (30 April 2019) | Viewed by 63772
Special Issue Editors
Interests: noncoding RNAs; micro-RNAs; prostate cancer; nanotechnological delivery of anticancer drugs and nucleic acids; diagnostic markers in cancer; urotensin II receptor; next-generation sequencing; predictive markers of response; circulating tumor cells
Special Issues, Collections and Topics in MDPI journals
Interests: aging; oxidative stress; nitric oxide; endothelial cells; endothelial progenitor cells; angiogenesis; inflammation; cell senescence; apoptosis; atherosclerosis; diabetes, endothelial dysfunction, sirtuins and cardiovascular disease; natural products; betaines; health; bioactive compounds; free radicals; antioxidants; ergothioneine; cell cycle; cancer-related biochemical pathways; cell proliferation; senescence; cancer cell death; epigenetic regulation; sirtuins and cancer
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Sirtuins, a family of nicotine adenine dinucleotide (NAD+)-dependent deacetylases that target histone and non-histone proteins, are crucial in the crosstalk between the environment and genome. Other factors contributing to aging and human diseases, including diabetes and cancer, are epigenetic signalings that include both DNA methylation and noncoding RNA interference. In the past few years, basic and translational research has been focused on sirtuins for their central role in the control of cell metabolism and in the regulation of many cellular functions, including DNA repair, inflammatory response, cell cycle and apoptosis. The field of sirtuins and epigenetic regulation of genome integrity and longevity is still capturing the attention of scientists, as well as the identification of novel modulators able to target with high specificity the pathways of chronic-degenerative disease. Moreover, the discovery of non-coding RNAs has disclosed a new scenario for the determination of novel molecular targets in the treatment of chronic degenerative diseases including cancer and metabolic diseases.
This Special Issue of the International Journal of Molecular Sciences will focus on recent advances on “Sirtuins and Epigenetics in Aging and Diseases”, including new insights into the molecular epigenetic mechanisms of aging, cancer, metabolic disorders, and cardiovascular disease. Moreover, emerging data on natural or synthetic epigenetic modulators in relation with new therapeutic options are welcome.
Prof. Dr. Michele Caraglia
Prof. Dr. Maria Luisa Balestrieri
Guest Editors
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Keywords
- Epigenetics
- Sirtuins
- Aging
- Cancer
- Cardiovascular disease
- miRNA
- long non-coding RNAs
- Inflammation
- Therapeutics
- Diabetes
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