Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
8.1
4.9
Journals
IJMS
Special Issues
Lipid Metabolism and Gene Expression in Skin and Skin Diseases
ijms-logo
Submit to IJMS Review for IJMS Propose a Special Issue

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

Lipid Metabolism and Gene Expression in Skin and Skin Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: closed (28 February 2022) | Viewed by 18488

Special Issue Editors

Dr. Dániel Törőcsik

E-Mail Website
Guest Editor
Department of Dermatology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary
Interests: acne; sebocytes; lipids, isotretinoin; skin inflammation
Special Issues, Collections and Topics in MDPI journals
Dr. Florian Gruber

E-Mail Website
Guest Editor
Department of Dermatology, Medical University of Vienna, Vienna, Austria
Interests: Oxidized Lipids; Skin Epilipidome; Aging; Cellular Senescence; Multimodal Imaging

Special Issue Information

Dear Colleagues,

Research in recent decades has revealed that lipids do not only cover the skin, contributing to the lipid barrier and influencing the microbiome, but may also accumulate within the dermis, which results in a microenvironment that may alter gene expression and, with that, the function of epidermal and dermal cells.

Although keratinocytes with sebaceous glands are considered to be the main source of skin lipids, the signals that regulate their lipid production and change their lipid profile and the relevance that those may have in disease pathogenesis are yet to be characterized in full detail. Importantly, despite the promising results from modifying various lipid-induced signaling pathways to treat skin diseases, such as the ones mediated via lipid activated hormone receptors such as PPARs or RARs, our knowledge on the therapeutic potential in the pathways that lipids may induce in both stromal and immune cells is also limited.

In this dedicated issue, we therefore welcome both basic and translational research as well as review articles that aim to introduce the possible involvement of lipids in maintaining skin homeostasis and in the pathogenesis of various skin diseases.

Dr. Dániel Törőcsik
Dr. Florian Gruber
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Skin
  • Lipid metabolism
  • Gene expression
  • Keratinocytes
  • Sebaceous glands
  • Immune- and other cells of the dermis
  • Acne, atopic dermatitis, and other skin diseases
  • Aging/anti-aging
  • Skin biomarkers
  • Oxidative stress

Published Papers (5 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

15 pages, 4164 KiB  
Article
Consequences of Autophagy Deletion on the Age-Related Changes in the Epidermal Lipidome of Mice
by Yiwen Yang, Christopher Kremslehner, Sophia Derdak, Christina Bauer, Sarah Jelleschitz, Ionela-Mariana Nagelreiter, Heidemarie Rossiter, Marie Sophie Narzt, Florian Gruber and Michaela Sochorová
Int. J. Mol. Sci. 2022, 23(19), 11110; https://doi.org/10.3390/ijms231911110 - 21 Sep 2022
Cited by 1 | Viewed by 1553
Abstract
Autophagy is a controlled mechanism of intracellular self-digestion with functions in metabolic adaptation to stress, in development, in proteostasis and in maintaining cellular homeostasis in ageing. Deletion of autophagy in epidermal keratinocytes does not prevent the formation of a functional epidermis and the [...] Read more.
Autophagy is a controlled mechanism of intracellular self-digestion with functions in metabolic adaptation to stress, in development, in proteostasis and in maintaining cellular homeostasis in ageing. Deletion of autophagy in epidermal keratinocytes does not prevent the formation of a functional epidermis and the permeability barrier but causes increased susceptibility to damage stress and metabolic alterations and accelerated ageing phenotypes. We here investigated how epidermal autophagy deficiency using Keratin 14 driven Atg7 deletion would affect the lipid composition of the epidermis of young and old mice. Using mass spectrometric lipidomics we found a reduction of age-related accumulation of storage lipids in the epidermis of autophagy-deficient mice, and specific changes in chain length and saturation of fatty acids in several lipid classes. Transcriptomics and immunostaining suggest that these changes are accompanied by changes in expression and localisation of lipid and fatty acid transporter proteins, most notably fatty acid binding protein 5 (FABP5) in autophagy knockouts. Thus, maintaining autophagic activity at an advanced age may be necessary to maintain epidermal lipid homeostasis in mammals. Full article
(This article belongs to the Special Issue Lipid Metabolism and Gene Expression in Skin and Skin Diseases)
►▼ Show Figures

Figure 1

17 pages, 7958 KiB  
Article
Transcriptional Differences in Lipid-Metabolizing Enzymes in Murine Sebocytes Derived from Sebaceous Glands of the Skin and Preputial Glands
by Katharina Klas, Dragan Copic, Martin Direder, Maria Laggner, Patricia Sandee Prucksamas, Florian Gruber, Hendrik Jan Ankersmit and Michael Mildner
Int. J. Mol. Sci. 2021, 22(21), 11631; https://doi.org/10.3390/ijms222111631 - 27 Oct 2021
Cited by 2 | Viewed by 2569
Abstract
Sebaceous glands are adnexal structures, which critically contribute to skin homeostasis and the establishment of a functional epidermal barrier. Sebocytes, the main cell population found within the sebaceous glands, are highly specialized lipid-producing cells. Sebaceous gland-resembling tissue structures are also found in male [...] Read more.
Sebaceous glands are adnexal structures, which critically contribute to skin homeostasis and the establishment of a functional epidermal barrier. Sebocytes, the main cell population found within the sebaceous glands, are highly specialized lipid-producing cells. Sebaceous gland-resembling tissue structures are also found in male rodents in the form of preputial glands. Similar to sebaceous glands, they are composed of lipid-specialized sebocytes. Due to a lack of adequate organ culture models for skin sebaceous glands and the fact that preputial glands are much larger and easier to handle, previous studies used preputial glands as a model for skin sebaceous glands. Here, we compared both types of sebocytes, using a single-cell RNA sequencing approach, to unravel potential similarities and differences between the two sebocyte populations. In spite of common gene expression patterns due to general lipid-producing properties, we found significant differences in the expression levels of genes encoding enzymes involved in the biogenesis of specialized lipid classes. Specifically, genes critically involved in the mevalonate pathway, including squalene synthase, as well as the sphingolipid salvage pathway, such as ceramide synthase, (acid) sphingomyelinase or acid and alkaline ceramidases, were significantly less expressed by preputial gland sebocytes. Together, our data revealed tissue-specific sebocyte populations, indicating major developmental, functional as well as biosynthetic differences between both glands. The use of preputial glands as a surrogate model to study skin sebaceous glands is therefore limited, and major differences between both glands need to be carefully considered before planning an experiment. Full article
(This article belongs to the Special Issue Lipid Metabolism and Gene Expression in Skin and Skin Diseases)
►▼ Show Figures

Figure 1

14 pages, 6647 KiB  
Article
Histone Deacetylase 1 Reduces Lipogenesis by Suppressing SREBP1 Transcription in Human Sebocyte Cell Line SZ95
by Hye Sun Shin, Yuri Lee, Mi Hee Shin, Soo Ick Cho, Christos C. Zouboulis, Min Kyoung Kim, Dong Hun Lee and Jin Ho Chung
Int. J. Mol. Sci. 2021, 22(9), 4477; https://doi.org/10.3390/ijms22094477 - 25 Apr 2021
Cited by 6 | Viewed by 3699
Abstract
Proper regulation of sebum production is important for maintaining skin homeostasis in humans. However, little is known about the role of epigenetic regulation in sebocyte lipogenesis. We investigated histone acetylation changes and their role in key lipogenic gene regulation during sebocyte lipogenesis using [...] Read more.
Proper regulation of sebum production is important for maintaining skin homeostasis in humans. However, little is known about the role of epigenetic regulation in sebocyte lipogenesis. We investigated histone acetylation changes and their role in key lipogenic gene regulation during sebocyte lipogenesis using the human sebaceous gland cell line SZ95. Sebocyte lipogenesis is associated with a significant increase in histone acetylation. Treatment with anacardic acid (AA), a p300 histone acetyltransferase inhibitor, significantly decreased the lipid droplet number and the expression of key lipogenic genes, including sterol regulatory-binding protein 1 (SREBP1), fatty acid synthase (FAS), and acetyl-CoA carboxylase (ACC). In contrast, treatment with trichostatin A (TSA), a histone deacetylase (HDAC) inhibitor, increased the expression of these genes. Global HDAC enzyme activity was decreased, and HDAC1 and HDAC2 expression was downregulated during sebaceous lipogenesis. Interestingly, HDAC1 knockdown increased lipogenesis through SREBP1 induction, whereas HDAC1 overexpression decreased lipogenesis and significantly suppressed SREBP1 promoter activity. HDAC1 and SREBP1 levels were inversely correlated in human skin sebaceous glands as demonstrated in immunofluorescence images. In conclusion, HDAC1 plays a critical role in reducing SREBP1 transcription, leading to decreased sebaceous lipogenesis. Therefore, HDAC1 activation could be an effective therapeutic strategy for skin diseases related to excessive sebum production. Full article
(This article belongs to the Special Issue Lipid Metabolism and Gene Expression in Skin and Skin Diseases)
►▼ Show Figures

Figure 1

Review

Jump to: Research

20 pages, 1410 KiB  
Review
Atopic Dermatitis: The Fate of the Fat
by Petra Pavel, Stefan Blunder, Verena Moosbrugger-Martinz, Peter M. Elias and Sandrine Dubrac
Int. J. Mol. Sci. 2022, 23(4), 2121; https://doi.org/10.3390/ijms23042121 - 14 Feb 2022
Cited by 15 | Viewed by 4687
Abstract
Atopic dermatitis (AD) is a chronic and relapsing inflammatory skin disease in which dry and itchy skin may develop into skin lesions. AD has a strong genetic component, as children from parents with AD have a two-fold increased chance of developing the disease. [...] Read more.
Atopic dermatitis (AD) is a chronic and relapsing inflammatory skin disease in which dry and itchy skin may develop into skin lesions. AD has a strong genetic component, as children from parents with AD have a two-fold increased chance of developing the disease. Genetic risk loci and epigenetic modifications reported in AD mainly locate to genes involved in the immune response and epidermal barrier function. However, AD pathogenesis cannot be fully explained by (epi)genetic factors since environmental triggers such as stress, pollution, microbiota, climate, and allergens also play a crucial role. Alterations of the epidermal barrier in AD, observed at all stages of the disease and which precede the development of overt skin inflammation, manifest as: dry skin; epidermal ultrastructural abnormalities, notably anomalies of the lamellar body cargo system; and abnormal epidermal lipid composition, including shorter fatty acid moieties in several lipid classes, such as ceramides and free fatty acids. Thus, a compelling question is whether AD is primarily a lipid disorder evolving into a chronic inflammatory disease due to genetic susceptibility loci in immunogenic genes. In this review, we focus on lipid abnormalities observed in the epidermis and blood of AD patients and evaluate their primary role in eliciting an inflammatory response. Full article
(This article belongs to the Special Issue Lipid Metabolism and Gene Expression in Skin and Skin Diseases)
►▼ Show Figures

Figure 1

13 pages, 446 KiB  
Review
Angioedema and Fatty Acids
by Akane Wada, Yu Sawada, Hitomi Sugino and Motonobu Nakamura
Int. J. Mol. Sci. 2021, 22(16), 9000; https://doi.org/10.3390/ijms22169000 - 20 Aug 2021
Cited by 3 | Viewed by 4827
Abstract
Angioedema is a life-threatening emergency event that is associated with bradykinin and histamine-mediated cascades. Although bradykinin-mediated angioedema currently has specific therapeutic options, angioedema is sometimes intractable with current treatments, especially histamine-mediated angioedema, suggesting that some other mediators might contribute to the development of [...] Read more.
Angioedema is a life-threatening emergency event that is associated with bradykinin and histamine-mediated cascades. Although bradykinin-mediated angioedema currently has specific therapeutic options, angioedema is sometimes intractable with current treatments, especially histamine-mediated angioedema, suggesting that some other mediators might contribute to the development of angioedema. Fatty acids are an essential fuel and cell component, and act as a mediator in physiological and pathological human diseases. Recent updates of studies revealed that these fatty acids are involved in vascular permeability and vasodilation, in addition to bradykinin and histamine-mediated reactions. This review summarizes each fatty acid’s function and the specific receptor signaling responses in blood vessels, and focuses on the possible pathogenetic role of fatty acids in angioedema. Full article
(This article belongs to the Special Issue Lipid Metabolism and Gene Expression in Skin and Skin Diseases)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-5
Back to TopTop