Stem Cell Research: Discovering the Mechanistic Understanding for Therapeutic Application
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (15 July 2024) | Viewed by 5473
Special Issue Editor
Special Issue Information
Dear Colleagues,
Stem cells have become a cornerstone of emerging regenerative medicine strategies, aiming to utilize tissue repair to restore function to cells damaged as a result of injury, ageing or disease. There is, therefore, a critical need to strengthen our understanding of the underpinning biological mechanisms and pathways that determine how these regenerative cells self-renew and differentiate, with the aim of optimizing protocols for maximal therapeutic efficacy and supporting the definition of product specification for regulatory approvals. This Special Issue aims to address unresolved problems in the therapeutic application of stem cells at the molecular, cellular, tissue, organ and system levels, seeking to advance existing techniques and determine novel ways of determining how stem cells can be used within the field of regenerative medicine.
This Special Issue welcomes original research articles, reviews, methods and other article types focusing on (but not limited to) the following areas:
- Mechanisms of pluripotency/multipotency and self-renewal;
- Mechanisms of cell lineage differentiation and the determination of therapeutic function;
- Advanced culture methods for the scale-up and production of therapeutic products;
- Bioengineering, including the combination of stem cells with biomaterials;
- Preclinical studies investigating stem cell safety and efficacy;
- Investigational studies of stem cell safety and efficacy in clinic.
Dr. Rachel A. Oldershaw
Guest Editor
Manuscript Submission Information
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Keywords
- pluripotent stem cells
- adult stem cells
- bioengineering
- regenerative medicine
- cell therapy