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Antiphospholipid Syndrome: From Pathophysiology to Therapy

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (29 February 2024) | Viewed by 1069

Special Issue Editor

Special Issue Information

Dear Colleagues,

We are pleased to invite you to contribute your research to the Special Issue “Antiphospholipid Syndrome: From Pathophysiology to Therapy”.

Antiphospholipid syndrome is an autoimmune systemic disorder characterized by arterial, venous, or small vessel thrombosis and/or recurrent early pregnancy loss, fetal loss, or pregnancy morbidity in the setting of documented persistent anti-phospholipid antibodies that include the lupus anticoagulant, or moderate-high titer anticardiolipin, or anti-beta 2Glycoprotein I antibodies. New research shows that APS has an estimated prevalence of about 50/100,000 population, and can occur both in patients with underlying autoimmune disease, infections, malignancies, drugs (secondary APS), and in patients without any concomitant clinical conditions (primary APS).

This Special Issue is open for basic research, and will also cover original articles as well as reviews on the following topics:

  • Antiphospholipid antibodies: pathophysiology and molecular mechanisms;
  • Clinical features of antiphospholipid syndrome;
  • Traditional and innovative therapeutic approaches for antiphospholipid syndrome.

Prof. Dr. Cristina Belizna
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Research

15 pages, 904 KiB  
Article
Quantification of Antiphospholipid Antibodies: The Importance of Using an Appropriate Methodology for Each Clinical Profile
by Oscar Cabrera-Marante, Sara Garcinuño, Daniel Enrique Pleguezuelo, Francisco J. Gil-Etayo, Iulian Tenica, Edgard Rodríguez de Frías, Denis Zafra, Nerea Castro, Estela Paz-Artal, Antonio Serrano and Manuel Serrano
Int. J. Mol. Sci. 2023, 24(24), 17373; https://doi.org/10.3390/ijms242417373 - 12 Dec 2023
Viewed by 894
Abstract
The presence of antiphospholipid antibodies (aPLs) is associated with antiphospholipid syndrome (APS), characterized by thrombosis and obstetric morbidity. aPLs included in APS classification criteria are lupus anticoagulant, anti-cardiolipin and anti-beta-2-glycoprotein-I of IgG or IgM isotypes. Enzyme-linked immunosorbent assay is the most used diagnostic [...] Read more.
The presence of antiphospholipid antibodies (aPLs) is associated with antiphospholipid syndrome (APS), characterized by thrombosis and obstetric morbidity. aPLs included in APS classification criteria are lupus anticoagulant, anti-cardiolipin and anti-beta-2-glycoprotein-I of IgG or IgM isotypes. Enzyme-linked immunosorbent assay is the most used diagnostic technique to determine aPLs. Recently, new automated technologies mainly based in antigen-coated beads have been developed. The aim is to compare a fluorescence enzyme immunoassay (M1) and an antigen-coated bead assay (M2) in obstetric and thrombotic APS patients. All samples from the first 1020 patients received in the Immune Service Laboratory (Hospital 12 de Octubre) during the recruitment period, without exclusions, were analysed for aPLs. The weighted kappa for both methods in all the patients was 0.39 (0.30–0.47). Agreement increased to 0.56 (0.38–0.73) in patients with autoimmune disease. Sensitivity and specificity obtained for M1 were 17.1% and 89.3%, respectively, and 12.7% and 91.4% for M2. The sensibility and specificity of IgG isotypes were higher than the IgM ones. Regarding obstetric patients, M1 obtained significant diagnostic performance and had more sensitivity 23.75 (14.95–34.58) compared to M2 12.50 (6.16–21.79). In conclusion, clinical suspicion-based method selection for aPLs should be considered. To identify obstetric APS patients, solid phase methods remain more preferable. Full article
(This article belongs to the Special Issue Antiphospholipid Syndrome: From Pathophysiology to Therapy)
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