Molecular Mechanisms of Sjögren's Syndrome, 4th Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 20 October 2025 | Viewed by 1328
Special Issue Editor
Interests: systemic lupus erythematosus; sjögren’s syndrome; prolidase deficiency; free radical biology; experimental urolithiasis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Sjögren’s syndrome (SS) is a systemic autoimmune rheumatic disorder characterized by B-cells’ infiltration of exocrine glands and the production of autoantibodies to self-antigens, such as Ro60 (SS-A), La (SS-B), and muscarinic 3 receptors. The most common symptoms of SS are dry eyes (keratoconjunctivitis sicca), dry mouth (xerostomia), and extreme tiredness. Additional symptoms include dryness of the skin, nose, throat, and vagina; arthralgias and myalgias; peripheral neuropathies; pulmonary, thyroid, and renal disorders; and lymphoma. Increased levels of tissue and serum cytokines and tissue fibrosis are also seen in patients with SS. Females account for 90% of all SS cases. Two age peaks have been identified for primary SS: the first is after menarche (twenties to thirties), and the second is after menopause (mid-fifties). SS can occur alone (primary SS) or along with another autoimmune diseases (secondary SS), such as systemic lupus erythematosus, rheumatoid arthritis, autoimmune hypothyroidism, and systemic sclerosis. The molecular mechanisms mediating pathological dysfunction in SS remain to be elucidated despite there being extensive studies investigating the underlying cause of Sjögren’s syndrome. There is currently no cure for Sjögren's syndrome, and treatment is mainly palliative.
In this Special Issue of IJMS, we seek articles that can better explain the molecular mechanisms mediating the pathological conditions of Sjögren’s syndrome. We welcome articles that provide insights into the molecular aspects of the initiation and progression of the disease by glandular vascular endothelial cells, environmental triggers, free radical-mediated oxidative damage, the cytokine activation of lymphocytes, glandular lymphocyte and dendritic cell homing, the structure and function of autoantigens and autoantibody induction, germinal center-like structure formation, and the apoptosis of glandular cells. We also welcome review papers in these areas and articles describing novel therapeutic targets and treatment options, new diagnostic tools, and biomarkers.
Dr. Biji Theyilamannil Kurien
Guest Editor
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Keywords
- autoimmunity
- sjögren’s syndrome
- autoantibodies
- salivary gland
- lacrimal gland
- dry eyes/mouth
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