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Venous Thromboembolism, Coagulation, Metabolism and Cancer
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Venous Thromboembolism, Coagulation, Metabolism and Cancer

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: closed (30 October 2022) | Viewed by 3530

Special Issue Editors

Prof. Dr. Antonino Tuttolomondo

E-Mail Website
Guest Editor
Biomedical Department of Internal Medicine and Medical Specialties (Di.Bi.M.I.S), University of Palermo, 90133 Palermo, Italy
Interests: ischemic stroke in diabetes; diabetic foot; Anderson-Fabry disease; cytokines
Special Issues, Collections and Topics in MDPI journals
Dr. Vittoriano Della Corte

E-Mail Website
Co-Guest Editor
Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (ProMISE), University of Palermo, Palermo, Italy
Interests: vascular ultrasound; echocolordoppler; atherosclerosis; venous thrombosis

Special Issue Information

Dear Colleagues,

Despite advances in research, venous thromboembolism (VTE) continues to be a significant burden for public health.A large body of literature has confirmed the link between VTE and cancer. However, the specific mechanisms leading to abnormalities in Virchow’s triad in cancer patients, particularly the effect on the host haemostatic system to promote the prothrombotic state, are not well understood. They may be tumour-specific, as different cancer types have varying risk rates for cancer-associated thrombosis. An increased risk of VTE has also been observed in metabolic disorders such as diabetes mellitus or metabolic syndrome, but the exact pathophysiological process underlying this association is still unclear.The application of metabolomics profiling in the area of vascular diseases may become a turning point in early diagnosis and patient management.The term ‘metabolomics’ refers to the comprehensive and systematic profiling of all low-molecular-weight compounds which are intermediate or final products of metabolism (e.g., carnitine, phenylalanine, 3-hydroxybutarate and many others) generated as a product of biochemical and physiological processes in the body and present in differential abundance in biofluids, cells and tissues. Despite the latest discoveries we still do not understand the mechanisms and pathways responsible for the occurrence of the observed alterations.This Special Issue attempts to explore the recent advances in venous thromboembolism.

This Special Issue welcomes original research and review papers that further clarify the link between VTE, cancer, metabolic alterations and the aspects concerning the metabolomics of VTE.

Prof. Dr. Antonino Tuttolomondo
Dr. Vittoriano Della Corte
Guest Editors

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Published Papers (2 papers)

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Research

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15 pages, 5223 KiB  
Article
Monoglyceride Lipase Deficiency Is Associated with Altered Thrombogenesis in Mice
by Madeleine Goeritzer, Katharina B. Kuentzel, Sarah Beck, Melanie Korbelius, Silvia Rainer, Ivan Bradić, Dagmar Kolb, Marion Mussbacher, Waltraud C. Schrottmaier, Alice Assinger, Axel Schlagenhauf, René Rost, Benjamin Gottschalk, Thomas O. Eichmann, Thomas Züllig, Wolfgang F. Graier, Nemanja Vujić and Dagmar Kratky
Int. J. Mol. Sci. 2023, 24(4), 3116; https://doi.org/10.3390/ijms24043116 - 4 Feb 2023
Viewed by 1663
Abstract
Monoglyceride lipase (MGL) hydrolyzes monoacylglycerols (MG) to glycerol and one fatty acid. Among the various MG species, MGL also degrades 2-arachidonoylglycerol, the most abundant endocannabinoid and potent activator of the cannabinoid receptors 1 and 2. We investigated the consequences of MGL deficiency on [...] Read more.
Monoglyceride lipase (MGL) hydrolyzes monoacylglycerols (MG) to glycerol and one fatty acid. Among the various MG species, MGL also degrades 2-arachidonoylglycerol, the most abundant endocannabinoid and potent activator of the cannabinoid receptors 1 and 2. We investigated the consequences of MGL deficiency on platelet function using systemic (Mgl−/−) and platelet-specific Mgl-deficient (platMgl−/−) mice. Despite comparable platelet morphology, loss of MGL was associated with decreased platelet aggregation and reduced response to collagen activation. This was reflected by reduced thrombus formation in vitro, accompanied by a longer bleeding time and a higher blood volume loss. Occlusion time after FeCl3-induced injury was markedly reduced in Mgl−/− mice, which is consistent with contraction of large aggregates and fewer small aggregates in vitro. The absence of any functional changes in platelets from platMgl−/− mice is in accordance with lipid degradation products or other molecules in the circulation, rather than platelet-specific effects, being responsible for the observed alterations in Mgl−/− mice. We conclude that genetic deletion of MGL is associated with altered thrombogenesis. Full article
(This article belongs to the Special Issue Venous Thromboembolism, Coagulation, Metabolism and Cancer)
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Review

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15 pages, 985 KiB  
Review
The Role of Biomarkers, Metabolomics, and COVID-19 in Venous Thromboembolism—A Review of Literature
by Vittoriano Della Corte, Renata Riolo, Stefania Scaglione, Rosaria Pecoraro and Antonino Tuttolomondo
Int. J. Mol. Sci. 2023, 24(17), 13411; https://doi.org/10.3390/ijms241713411 - 29 Aug 2023
Cited by 3 | Viewed by 1460
Abstract
In recent years, the field of venous thromboembolism has undergone numerous innovations, starting from the recent discoveries on the role of biomarkers, passing through the role of metabolomics in expanding our knowledge on pathogenic mechanisms, which have opened up new therapeutic targets. A [...] Read more.
In recent years, the field of venous thromboembolism has undergone numerous innovations, starting from the recent discoveries on the role of biomarkers, passing through the role of metabolomics in expanding our knowledge on pathogenic mechanisms, which have opened up new therapeutic targets. A variety of studies have contributed to characterizing the metabolic phenotype that occurs in venous thromboembolism, identifying numerous pathways that are altered in this setting. Among these pathways are the metabolism of carnitine, tryptophan, purine, and fatty acids. Furthermore, new evidence has emerged with the recent COVID-19 pandemic. Hypercoagulability phenomena induced by this viral infection appear to be related to altered von Willebrand factor activity, alteration of the renin–angiotensin–aldosterone system, and dysregulation of both innate and adaptive immunity. This is the first literature review that brings together the most recent evidence regarding biomarkers, metabolomics, and COVID-19 in the field of venous thromboembolism, while also mentioning current therapeutic protocols. Full article
(This article belongs to the Special Issue Venous Thromboembolism, Coagulation, Metabolism and Cancer)
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