From Molecules to Tissues: Health, Injury and Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biophysics".
Deadline for manuscript submissions: closed (10 October 2023) | Viewed by 2677
Special Issue Editor
Interests: protein structure; X-ray diffraction; collagen; extracellular matrix; neuroscience; traumatic brain injury
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Homeostasis in humans is a complex process consisting of cellular and sub-cellular molecular interactions and responses that affect tissue structure and function. The body maintains and regulates these processes and, to a certain extent, is able to repair imbalances that may occur due to pathologies arising from injury and/or disease. However, severe damage from chemical, mechanical and/or other biological insults to tissues is often serious to the extent that the body is incapable of taking restorative actions in a reasonable time. These situations require us to understand the mechanics and mechanisms of homeostasis at these various hierarchical levels at a high level of detail, both individually and in relation to the tissue-level response.
Recent advancements in determining multi-scale tissue properties and attributing them to total body functions have improved drastically. X-ray diffraction (XRD), electron microscopy (EM) and cryo-EM are amongst the most popular techniques currently deployed to develop high-resolution and high-fidelity mathematical models and simulations of various human organs, organ systems and full bodies under physiological and pathological conditions. This Special Issue is focused on collecting cutting-edge research elucidating the multi-scale structure and function of human and animal tissues and their potential use in mathematical modeling of these tissues at all hierarchical levels. That is, contributions relevant to any part of this scale, and those that are multi-scale, are especially welcome. Manuscripts that describe the development of methods to determine these properties will also be accepted, alongside those that describe mathematical models based on previously performed experimental works.
Prof. Dr. Joseph Orgel
Guest Editor
Manuscript Submission Information
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