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Toxicity and Biomedical Applications of Nano Materials

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 10993

Special Issue Editor


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Guest Editor
Laboratory of Nanoparticles, V. V. Voevodsky Institute of Chemical Kinetics and Combustion, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia
Interests: hybrid inorganic–organic nanobiocomposites with a set of specified physicochemical and biological properties; theranostics; chemistry of natural compounds; chemistry of organoelement compounds
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Special Issue Information

Dear Colleagues,

The modern flow of scientific information on the various unusual effects of nanostructured materials is steadily increasing. This is largely due to the size-conditioned (quantum-sized) physical and chemical properties of nanostructures, as well as their surfaces, which are a special state of matter that greatly contributes to nanosystems. Due to these unusual properties and high demand for the effects caused by them, nanomaterials are intensively permeating almost all areas of industry, economic activity, and even everyday life. The complex of unusual physicochemical properties also inevitably manifests itself in the unusual biological activity of nanomaterials, which is increasingly becoming used in various biomedical applications. In particular, the combination of a high biological activity and a regular response to various types of minimal or non-invasive penetrating radiation in the same nanostructured material opens up a unique opportunity to implement the principles of parallel therapy and diagnostics (theranostics) in one session using the same nanopreparation. At the same time, special biomedical opportunities for the continuous active control of therapeutic processes are made possible by the implementation of a continuous direct and reverse monitoring connection, “I see - what I treat, I treat - what I see”, in real-time for the development of the entire therapeutic process. Today, a huge number of both naturally nanostructured and man-made substances and systems are therefore in close contact and inevitably interact, surrounding humans and other living organisms. In this context, a complicated array of fundamental environmental problems is growing, the key issue of which is the biosafety of nanostructured substances. Here, one of the most important roles is played by the toxicology of nanosubstances and their systems, and when creating nanomaterials for biomedical purposes, their toxicological characteristics are of decisive importance. As is seen elsewhere in the manifestation of the unusual size-dependent properties of nanomaterials, their size-related toxicity is of particular interest.              

In this Special Issue, entitled "Toxicity and Biomedical Applications of Nanomaterials", we will consider the problems of the structural–biological relationship in the properties of nanomaterials and the principles of designing new nanomaterials for applications in biomedicine. Original research and reviews in this area are encouraged, with a focus on all aspects of the design, characterization, testing, biosafety and toxicity assessment of nanostructured materials and their systems for biomedical applications.

Dr. Boris Sukhov
Guest Editor

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Published Papers (1 paper)

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25 pages, 3359 KiB  
Review
Liposomes for Tumor Targeted Therapy: A Review
by Shile Wang, Yanyu Chen, Jiancheng Guo and Qinqin Huang
Int. J. Mol. Sci. 2023, 24(3), 2643; https://doi.org/10.3390/ijms24032643 - 31 Jan 2023
Cited by 72 | Viewed by 10487
Abstract
Liposomes, the most widely studied nano-drug carriers in drug delivery, are sphere-shaped vesicles consisting of one or more phospholipid bilayers. Compared with traditional drug delivery systems, liposomes exhibit prominent properties that include targeted delivery, high biocompatibility, biodegradability, easy functionalization, low toxicity, improvements in [...] Read more.
Liposomes, the most widely studied nano-drug carriers in drug delivery, are sphere-shaped vesicles consisting of one or more phospholipid bilayers. Compared with traditional drug delivery systems, liposomes exhibit prominent properties that include targeted delivery, high biocompatibility, biodegradability, easy functionalization, low toxicity, improvements in the sustained release of the drug it carries and improved therapeutic indices. In the wake of the rapid development of nanotechnology, the studies of liposome composition have become increasingly extensive. The molecular diversity of liposome composition, which includes long-circulating PEGylated liposomes, ligand-functionalized liposomes, stimuli-responsive liposomes, and advanced cell membrane-coated biomimetic nanocarriers, endows their drug delivery with unique physiological functions. This review describes the composition, types and preparation methods of liposomes, and discusses their targeting strategies in cancer therapy. Full article
(This article belongs to the Special Issue Toxicity and Biomedical Applications of Nano Materials)
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