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New Frontiers of Traumatic Brain Injury Management

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (31 August 2021) | Viewed by 3232

Special Issue Editor


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Guest Editor
Eliachar Research Laboratory, Galilee Medical Center, P.O. Box 21, Nahariya 2210001, Israel
Interests: traumatic brain injury; cerebral metabolism; cerebral blood flow; mitochondria; neuroprotection

Special Issue Information

Dear Colleagues,

Traumatic brain injury (TBI) represents a major therapeutic challenge responsible for more than 50,000 deaths every year in the US alone, with a phenomenal psychological, social and financial burden. Despite tremendous efforts in both clinical and experimental research, the mainstay of TBI management still relies on basic mechanistic principles of intracranial pressure relief and does not address the complex pathophysiology that underlies the process of secondary brain damage. Discouraging results of numerous clinical studies based on translational research, however, have not hampered neuroscientists’ continued attempts to elucidate the different pathways of secondary traumatic neuronal damage, looking for novel avenues of neuroprotection.

This Special Issue, "New frontiers of TBI management”, of the International Journal of Molecular Sciences will comprise a selection of research papers and reviews that will contribute to understanding the efficacy, safety, and mechanisms of medicines used in the treatment of traumatic brain injury.

Prof. Dr. Jean-Francois Soustiel
Guest Editor

Manuscript Submission Information

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Published Papers (1 paper)

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Research

26 pages, 24040 KiB  
Article
Co-Ultra PEALut Enhances Endogenous Repair Response Following Moderate Traumatic Brain Injury
by Michela Campolo, Rosalia Crupi, Marika Cordaro, Salvatore Massimo Cardali, Alessio Ardizzone, Giovanna Casili, Sarah Adriana Scuderi, Rosalba Siracusa, Emanuela Esposito, Alfredo Conti and Salvatore Cuzzocrea
Int. J. Mol. Sci. 2021, 22(16), 8717; https://doi.org/10.3390/ijms22168717 - 13 Aug 2021
Cited by 22 | Viewed by 2820
Abstract
This study aimed to assess the neuro-regenerative properties of co-ultramicronized PEALut (Glialia®), composed of palmitoylethanolamide (PEA) and the flavonoid luteolin (Lut), in an in vivo model of traumatic brain injury (TBI) and patients affected by moderate TBI. An increase in neurogenesis [...] Read more.
This study aimed to assess the neuro-regenerative properties of co-ultramicronized PEALut (Glialia®), composed of palmitoylethanolamide (PEA) and the flavonoid luteolin (Lut), in an in vivo model of traumatic brain injury (TBI) and patients affected by moderate TBI. An increase in neurogenesis was seen in the mice at 72 h and 7 d after TBI. The co-ultra PEALut treatment helped the neuronal reconstitution process to restore the basal level of both novel and mature neurons; moreover, it induced a significant upregulation of the neurotrophic factors, which ultimately led to progress in terms of memory recall during behavioral testing. Moreover, our preliminary findings in a clinical trial suggested that Glialia® treatment facilitated neural recovery on working memory. Thus, co-ultra PEALut (Glialia®) could represent a valuable therapeutic agent for intensifying the endogenous repair response in order to better treat TBI. Full article
(This article belongs to the Special Issue New Frontiers of Traumatic Brain Injury Management)
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