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Current Research in Antimicrobial Natural Products

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 20 September 2024 | Viewed by 1071

Special Issue Editor


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Guest Editor
Institute of Food Science and Technology (ICTAL), La Serna 58, 24007 León, Spain
Interests: foodborne pathogens; microbiology of food; natural extract from palantas; propolis; bioactive compounds

Special Issue Information

Dear Colleagues,

There are several microorganisms which possess pathogenic traits. Due to the contamination of these pathogenic microorganisms, food safety is becoming a major concern on a global level. Annually, 33 million people are affected by foodborne illness across the globe. Many of the pathogenic microbes, on account of their exceptional surviving conditions, have a potential risk of surviving even after cleaning and sterilization processes. Therefore, they become a great risk of illness. In addition, the Food and Agriculture Organization of the United Nations carried out a study revealing that one-third (1.3 billion tons per year) of food production for human consumption is lost because of spoilage or waste. Although there is continuous development in food technology, the morbidity caused by foodborne illness, food loss, and biofilm formation are still prevailing, especially in developing countries. Both the health and economic sectors of countries worldwide suffer due to this threat. There is an increasing demand for natural compounds due to their efficacy against various microorganisms, and they are being considered as a safer option over synthetic ones. These products or compounds are obtained from different sources including bacteria, plants, animals, etc. All of them exert their action via certain mechanisms derived from their chemical composition and are considered helpful in the control of microorganisms and response to resistance to antibiotics.

The objective of this Special Issue of IJMS is to present the latest research on various aspects of natural antimicrobial products (bio-preservation) as strategies to control pathogenic and spoilage microorganisms. Original research and review articles are invited.

Dr. Jose Javier Sanz-Gómez
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • natural products
  • chemical composition
  • spoilage microorganisms
  • pathogens
  • food preservatives
  • biofilms
  • safety assessment
  • clean label
  • antibiotics resistance

Published Papers (1 paper)

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Research

21 pages, 4662 KiB  
Article
Regioselective and Stereoselective Synthesis of Parthenolide Analogs by Acyl Nitroso-Ene Reaction and Their Biological Evaluation against Mycobacterium tuberculosis
by Bruna Gioia, Francesca Ruggieri, Alexandre Biela, Valérie Landry, Pascal Roussel, Catherine Piveteau, Florence Leroux, Ruben C. Hartkoorn and Nicolas Willand
Int. J. Mol. Sci. 2023, 24(24), 17395; https://doi.org/10.3390/ijms242417395 (registering DOI) - 12 Dec 2023
Viewed by 761
Abstract
Historically, natural products have played a major role in the development of antibiotics. Their complex chemical structures and high polarity give them advantages in the drug discovery process. In the broad range of natural products, sesquiterpene lactones are interesting compounds because of their [...] Read more.
Historically, natural products have played a major role in the development of antibiotics. Their complex chemical structures and high polarity give them advantages in the drug discovery process. In the broad range of natural products, sesquiterpene lactones are interesting compounds because of their diverse biological activities, their high-polarity, and sp3-carbon-rich chemical structures. Parthenolide (PTL) is a natural compound isolated from Tanacetum parthenium, of the family of germacranolide-type sesquiterpene lactones. In recent years, parthenolide has been studied for its anti-inflammatory, antimigraine, and anticancer properties. Recently, PTL has shown antibacterial activities, especially against Gram-positive bacteria. However, few studies are available on the potential antitubercular activities of parthenolide and its analogs. It has been demonstrated that parthenolide’s biological effects are linked to the reactivity of α-exo-methylene-γ-butyrolactone, which reacts with cysteine in targeted proteins via a Michael addition. In this work, we describe the ene reaction of acylnitroso intermediates with parthenolide leading to the regioselective and stereoselective synthesis of new derivatives and their biological evaluation. The addition of hydroxycarbamates and hydroxyureas led to original analogs with higher polarity and solubility than parthenolide. Through this synthetic route, the Michael acceptor motif was preserved and is thus believed to be involved in the selective activity against Mycobacterium tuberculosis. Full article
(This article belongs to the Special Issue Current Research in Antimicrobial Natural Products)
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