Molecular Insights into Diabetic Nephropathy
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 June 2026 | Viewed by 1016
Special Issue Editor
Interests: kidney; blood pressure regulation; acute kidney injury; chronic kidney disease; diabetic nephropathy; CAKUT; renal carcinoma
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Diabetic kidney disease (DKD; diabetic nephropathy) is one of the most serious microvascular complications of diabetes mellitus, the leading cause of end-stage chronic kidney disease worldwide, and the principal diagnosis in more than 50% of individuals undergoing renal transplantation. Hyperglycemia and insulin resistance in diabetes lead to metabolic stress in different populations of renal cells, the most sensitive being podocytes, endothelial cells, and the epithelium of the proximal tubules. These changes result in mitochondrial dysfunction, oxidative stress, and the triggering of inflammatory pathways, eventually leading to cytoskeletal reorganization and fibrosis. While some aspects of the complex molecular processes underlying these pathophysiological processes are understood, the field still remains largely unexplored. Therefore, we encourage authors to submit original research and review articles focusing on the molecular underpinnings of diabetic kidney disease pathophysiology.
Prof. Dr. Natalija Filipović
Guest Editor
Manuscript Submission Information
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Keywords
- diabetic nephropathy
- hyperglycemia
- insulin resistance
- oxidative stress
- mitochondrial dysfunction
- chronic kidney disease
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