Targeted Treatments in Cancer: 2nd Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 20 July 2025 | Viewed by 5161
Special Issue Editor
Interests: biochemistry; radiobiology; pharmacology; molecular science; radiochemistry
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue is a continuation of our previous Special Issue, entitled "Targeted Treatments in Cancer".
In recent years, the survival rate of cancer patients has increased, due to the development of various treatments. However, some cancers, such as pancreatic cancer, are extremely resistant to treatment. One approach uses antibodies or chemicals conjugated to radionuclides, which provide specific radiotherapy. Several cancer-specific molecular targets (such as LAT1, highly expressed in tumor tissues) have been selected, and antibodies (i.e., 90Y-CD20 and 111In-CD20 antibodies, Zevalin®) have also been selected. Nuclear medicine treatment is less invasive than surgery, and is suitable for difficult-to-treat cancer cases. In particular, targeted α therapy (TAT) involves the selective delivery of α-emitters to tumors, using high linear energy transfer (LET) α-particles, while minimizing the damage caused to surrounding tissues. Radium-223 (223Ra) dichloride has been employed as a treatment for bone metastasis (i.e., Xofigo®), as well as for pain management. Radiopharmaceuticals constitute a practical and effective treatment, albeit with their restrictions. Actinium-225 (225At) and astatine-211 (211At) are promising radionuclides for TAT.We focus on researching the usefulness of nuclear medicine treatments, and we aim to drive the development of novel therapeutic agents. Since molecular biology and basic scientific studies are indispensable for the development of technology in nuclear medicine, we will prioritize basic research over clinical trials/data.
Prof. Dr. Kazuko Kaneda-Nakashima
Guest Editor
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Keywords
- TAT (targeting alpha therapy)
- nuclear medicine
- cancer treatment
- imaging
- radioisotope (RI)
- surface marker
- TRT (targeted radioisotope therapy)
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