Synthesis and Biological Evaluation of Pyrazole Derivatives
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".
Deadline for manuscript submissions: closed (30 July 2024) | Viewed by 2414
Special Issue Editors
Interests: medicinal chemistry; antiproliferative agents; antiviral agents; molecular docking; antioxidant compounds; protein kinase inhibitors; antibacterial agents
Special Issues, Collections and Topics in MDPI journals
Interests: medicinal chemistry; antiproliferative agents; neuroprotective agents; phosphodiesterase inhibitors; antioxidant compounds; protein kinase inhibitors; antibacterial agents
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Blockbuster drugs (e.g., Acomplia®, Celebrex®), as well as a number of promising compounds endowed with various biological activities, are characterized by the pyrazole substructure. Pyrazole-containing molecules display a broad range of biological activities, including anti-inflammatory, anticancer, antiviral, antibacterial, antifungal, and selective enzyme inhibition properties.
The pharmacological properties of this heterocycle are related to its particular chemical behavior. In fact, the two pyrazole nitrogen atoms (namely, “pyrrole-like” and “pyridine-like” nitrogen) are characterized by different electronic properties, allowing reactivity with both acids and basis. Furthermore, pyrazole is endowed with prototrophic tautomerism that can be relevant in interactions with several pharmacological targets.
This Special Issue highlights the interest of the scientific community in this heterocycle and will focus on medicinal chemistry studies oriented towards the design, synthesis, and biological characterization of novel, differently decorated pyrazole derivatives. The results reported in the Special Issue will further support medicinal chemists interested in exploiting the pharmaceutical potential of pyrazole-containing derivatives.
Dr. Andrea Spallarossa
Dr. Chiara Brullo
Guest Editors
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Keywords
- pyrazole compounds
- medicinal chemistry
- drug design
- drug synthesis
- biological properties
- drug discovery
- structure–activity relationships
- organic synthesis
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