Anesthetic and Sedative Actions on Nervous System Development
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: closed (29 February 2024) | Viewed by 700
Special Issue Editor
Special Issue Information
Dear Colleagues,
Studies from animal models including rodents and nonhuman primates have demonstrated that early developmental exposure to general anesthetic and sedative agents alters the development of the nervous system, and that these changes may have lasting, harmful effects. Investigators have demonstrated deficits in learning and memory as well as in affective behaviors, and a wide array of pathologic consequences including cell death, impaired neurogenesis, disruptions in axon and dendrite formation, loss of synapses, and aberrations in glial cell development, has been documented. The clinical significance of these findings in human pediatric patients remains unclear and thus an area of concern that requires further research in order to ensure that anesthesiologists and critical care physicians can provide the highest level of safety to vulnerable patients.
In this Special Edition, we are soliciting manuscripts ranging from original research to review articles that provide novel and timely insights into how anesthetics and sedatives act on nervous system development. Investigations that range from basic science to translation or clinical topics will be considered, with particular interest in newly discovered targets, novel phenotypes, and risk factors for vulnerability.
Since IJMS is a journal of molecular science, thus pure clinical studies will not be suitable for our journal. But clinical submissions with biomolecular experiments are welcomed.
Dr. Cyrus David Mintz
Guest Editor
Manuscript Submission Information
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