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State-of-the-Art Bioactives and Nutraceuticals in Japan
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State-of-the-Art Bioactives and Nutraceuticals in Japan

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: closed (25 January 2024) | Viewed by 5676

Special Issue Editors

Prof. Dr. Hiroko Isoda

E-Mail Website
Guest Editor
Faculty of Life and Environmental Sciences, University of Tsukuba, Ibaraki 305-8572, Japan
Interests: food functionality; natural compounds drug discovery; food and medicinal plants; bioassay; anti-aging; antidepressant; anti-anxiety; life style related disease prevention; melanogenesis; hair growth; AI-based functional food discovery and characterization
Dr. Shinya Takahashi

E-Mail Website
Guest Editor
Faculty of Life and Environmental Sciences, University of Tsukuba, Tennodai 1-1-1, Tsukuba, Ibaraki 305-8577, Japan
Interests: environmental stress; UV-B stress; biological effects of low-dose radiation; DNA repair; reactive oxygen species; biostimulant; environmental response; plant physiology
Dr. Kazunori Sasaki

E-Mail Website
Guest Editor
National Institute of Advanced Industrial Science and Technology (AIST), Tokyo 100-0013, Japan
Interests: natural compounds; neuroprotective activities; memory and cognitive function; anti-aging; antidepressants
Dr. Farhana Ferdousi

E-Mail Website
Guest Editor
Alliance for Research on the Mediterranean and North Africa (ARENA), University of Tsukuba, Tennodai 1-1-1, Tsukuba, Ibaraki 305-8577, Japan
Interests: bioinformatics; biostatistics; clinical trial and intervention study; neuronal diseases; metabolic diseases

Special Issue Information

Dear Colleagues,

This Collection aims to publish contributions that report on novel research findings regarding bioactive compounds and nutraceutical products in Japan. We welcome submissions and studies on nutritional applications using biological, chemical, cellular, molecular, and immunological methods. Topics include, but are not limited to:

  • the discovery of novel bioactive natural products
  • the role of these products in manipulating food structure and hence potential physiological mediation for human nutrition
  • the use of in vitro and in vivo bioactivity research using cell lines and animal models as exemplars of human physiology

The only limitation is that the main part of the study has to have been carried out in Japan or by Japanese researchers.

Importantly, the exact active ingredient of natural origin extract must be reported in the submitted research manuscript, since papers describing the effects of mixed extraction from natural origin are not in the scope of the journal.

Prof. Dr. Hiroko Isoda
Dr. Shinya Takahashi
Dr. Kazunori Sasaki
Dr. Farhana Ferdousi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioactive
  • nutraceutical
  • nutrient
  • health
  • diet
  • functional food
  • obesity
  • diabetes
  • cancer
  • cardiovascular and cerebrovascular diseases
  • vitamins
  • proteins
  • peptides
  • polysaccharides
  • carotenoids
  • polyphenols
  • phytosterols and isoflavones
  • saponins
  • phytic acid
  • probiotics
  • prebiotics
  • enzymes
  • flavonoids
  • caffeine
  • carnitine
  • choline
  • creatine
  • dithiolthiones
  • phytoestrogens
  • glucosinolates

Published Papers (3 papers)

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Research

25 pages, 6152 KiB  
Article
A Rare Olive Compound Oleacein Improves Lipid and Glucose Metabolism, and Inflammatory Functions: A Comprehensive Whole-Genome Transcriptomics Analysis in Adipocytes Differentiated from Healthy and Diabetic Adipose Stem Cells
by Rui Wang, Munkhzul Ganbold, Farhana Ferdousi, Kenichi Tominaga and Hiroko Isoda
Int. J. Mol. Sci. 2023, 24(13), 10419; https://doi.org/10.3390/ijms241310419 - 21 Jun 2023
Viewed by 1507
Abstract
Oleacein (OLE), a rare natural compound found in unfiltered extra virgin olive oil, has been shown to have anti-inflammatory and anti-obesity properties. However, little is known regarding the mechanisms by which OLE influences metabolic processes linked to disease targets, particularly in the context [...] Read more.
Oleacein (OLE), a rare natural compound found in unfiltered extra virgin olive oil, has been shown to have anti-inflammatory and anti-obesity properties. However, little is known regarding the mechanisms by which OLE influences metabolic processes linked to disease targets, particularly in the context of lipid metabolism. In the present study, we conducted whole-genome DNA microarray analyses in adipocytes differentiated from human adipose-derived stem cells (hASCs) and diabetic hASCs (d-hASCs) to examine the effects of OLE on modulating metabolic pathways. We found that OLE significantly inhibited lipid formation in adipocytes differentiated from both sources. In addition, microarray analysis demonstrated that OLE treatment could significantly downregulate lipid-metabolism-related genes and modulate glucose metabolism in both adipocyte groups. Transcription factor enrichment and protein–protein interaction (PPI) analyses identified potential regulatory gene targets. We also found that OLE treatment enhanced the anti-inflammatory properties in adipocytes. Our study findings suggest that OLE exhibits potential benefits in improving lipid and glucose metabolism, thus holding promise for its application in the management of metabolic disorders. Full article
(This article belongs to the Special Issue State-of-the-Art Bioactives and Nutraceuticals in Japan)
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21 pages, 4079 KiB  
Article
A Descriptive Whole-Genome Transcriptomics Study in a Stem Cell-Based Tool Predicts Multiple Tissue-Specific Beneficial Potential and Molecular Targets of Carnosic Acid
by Farhana Ferdousi, Kazunori Sasaki, Satoshi Fukumitsu, Hidetoshi Kuwata, Mitsutoshi Nakajima and Hiroko Isoda
Int. J. Mol. Sci. 2023, 24(9), 8077; https://doi.org/10.3390/ijms24098077 - 29 Apr 2023
Viewed by 1768
Abstract
Carnosic acid (CA) is a phenolic diterpene widely distributed in herbal plants, rosemary and sage. Although its medicinal properties, such as antioxidant, antimicrobial, and neuroprotective effects, have been well-documented, its relevant biochemical processes and molecular targets have not been fully explored yet. In [...] Read more.
Carnosic acid (CA) is a phenolic diterpene widely distributed in herbal plants, rosemary and sage. Although its medicinal properties, such as antioxidant, antimicrobial, and neuroprotective effects, have been well-documented, its relevant biochemical processes and molecular targets have not been fully explored yet. In the present study, we conducted an untargeted whole-genome transcriptomics analysis to investigate CA-induced early biological and molecular events in human amniotic epithelial stem cells (hAESCs) with the aim of exploring its multiple tissue-specific functionalities and potential molecular targets. We found that seven days of CA treatment in hAESCs could induce mesoderm-lineage-specific differentiation. Tissue enrichment analysis revealed that CA significantly enriched lateral plate mesoderm-originated cardiovascular and adipose tissues. Further tissue-specific PPI analysis and kinase and transcription factor enrichment analyses identified potential upstream regulators and molecular targets of CA in a tissue-specific manner. Gene ontology enrichment analyses revealed the metabolic, antioxidant, and antifibrotic activities of CA. Altogether, our comprehensive whole-genome transcriptomics analyses offer a thorough understanding of the possible underlying molecular mechanism of CA. Full article
(This article belongs to the Special Issue State-of-the-Art Bioactives and Nutraceuticals in Japan)
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20 pages, 7343 KiB  
Article
Botryococcus terribilis Ethanol Extract Exerts Anti-inflammatory Effects on Murine RAW264 Cells
by Shinya Takahashi, Farhana Ferdousi, Seri Yamamoto, Atsushi Hirano, Sachiko Nukaga, Hiroyuki Nozaki and Hiroko Isoda
Int. J. Mol. Sci. 2023, 24(7), 6666; https://doi.org/10.3390/ijms24076666 - 3 Apr 2023
Cited by 1 | Viewed by 1908
Abstract
The present study aimed to evaluate the effects of Botryococcus terribilis ethanol extract (BTEE) on lipopolysaccharide (LPS)-induced inflammation in RAW264 cells. BTEE significantly attenuated LPS-induced nitric oxide production and inflammatory cytokines release, including Ccl2, Cox2, and Il6. On the other [...] Read more.
The present study aimed to evaluate the effects of Botryococcus terribilis ethanol extract (BTEE) on lipopolysaccharide (LPS)-induced inflammation in RAW264 cells. BTEE significantly attenuated LPS-induced nitric oxide production and inflammatory cytokines release, including Ccl2, Cox2, and Il6. On the other hand, several anti-inflammatory mediators, such as Pgc1β and Socs1, were increased in BTEE-treated cells. Further, we performed an untargeted whole-genome microarray analysis to explore the anti-inflammatory molecular mechanism of BTEE. Enrichment analysis showed BTEE significantly downregulated ‘response to stimulus’, ‘locomotion’, and ‘immune system response’ and upregulated ‘cell cycle’ gene ontologies in both 6- and 17-h post-LPS stimulation conditions. Pathway analysis revealed BTEE could downregulate the expressions of chemokines of the CC and CXC subfamily, and cytokines of the TNF family, TGFβ family, IL1-like, and class I helical. PPI analysis showed AXL receptor tyrosine kinase (Axl), a receptor tyrosine kinase from the TAM family, and its upstream transcription factors were downregulated in both conditions. Node neighborhood analysis showed several Axl coexpressed genes were also downregulated. Further, kinase enrichment and chemical perturbation analyses supported Axl inhibition in BTEE-treated conditions. Altogether, these findings suggest anti-inflammatory effects of BTEE that are mediated via the suppression of pro-inflammatory cytokines and predict its potential as an Axl inhibitor. Full article
(This article belongs to the Special Issue State-of-the-Art Bioactives and Nutraceuticals in Japan)
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