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Recent Molecular Research in Virology and Oncology
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Recent Molecular Research in Virology and Oncology

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 20 January 2025 | Viewed by 2717

Special Issue Editors

Prof. Dr. Rui Medeiros

E-Mail Website
Guest Editor
Molecular Oncology and Viral Pathology Group, IPO Porto Research Center (CI-IPOP), Portuguese Oncology Institute of Porto (IPO Porto), 4200-072 Porto, Portugal
Interests: molecular oncology; cancer cachexia; precision medicine; pharmacogenomics; prognostic biomarkers; predictive biomarkers; microRNAs; genetic polymorphism; viral nucleic acids
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Paula Oliveira

E-Mail Website
Guest Editor
1. Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), Institute for Innovation, Capacity Building and Sustainability of Agri-Food Production (Inov4Agro), University of Trás-os-Montes and Alto Douro (UTAD), 5000-801 Vila Real, Portugal
2. Department of Veterinary Sciences, University of Trás-os-Montes and Alto Douro (UTAD), 5000-801 Vila Real, Portugal
Interests: animal models; in vivo studies; natural compounds
Special Issues, Collections and Topics in MDPI journals
Dr. Rui M. Gil da Costa

E-Mail Website
Guest Editor
1. Molecular Oncology and Viral Pathology Group, Research Center of IPO Porto (CI-IPOP) / RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto) / Porto Comprehensive Cancer Center (Porto.CCC), 4200-072 Porto, Portugal
2. Post-Graduate Programme in Adult Health (PPGSAD), Federal University of Maranhão, São Luís 65085-580, Brazil
3. Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), Institute for Innovation, Capacity Building and Sustainability of Agri-Food Production (Inov4Agro), University of Trás-os-Montes and Alto Douro (UTAD), 5000-801 Vila Real, Portugal
Interests: cancer cachexia; animal models of cancer
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Recent Molecular Research in Virology and Oncology is making significant contributions in advancing our understanding of the complex molecular mechanisms responsible for viral infections and cancer development. Scientific exploration is focusing mainly on four key research areas:

  1. Viral pathogenesis that identifies novel therapeutic targets for combating the disease caused by viruses;
  2. Tumor immunology that is exploring new biomarkers and immunotherapeutic targets for improving cancer treatment by investigating the interaction between tumors and the immune system;
  3. RNA biology that is studying the significant role of RNA processing, modifications, and silencing mechanisms in viral infections and cancer;
  4. Precision medicine that is developing personalized therapies based on genomic analysis or other molecular diagnostic techniques with the potential to revolutionize cancer treatment.

These ongoing research efforts bring together experts from various disciplines, including virology, immunology, molecular biology, and genetics, to develop innovative solutions for the prevention and treatment of viral infections and cancer. Recent advancements in molecular research have resulted in the discovery of new immunotherapeutic targets, biomarkers, and customized therapies, further fueling our newfound understanding of the complex interactions between viruses and cancer. As we continue to make progress in this field, we can expect further breakthroughs that will ultimately revolutionize how we prevent, diagnose, and treat viral infections and cancer, providing hope for improved patient outcomes.

Prof. Dr. Rui Medeiros
Prof. Dr. Paula Oliveira
Dr. Rui M. Gil da Costa
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • molecular research
  • virology
  • oncology
  • precision medicine
  • immunotherapy

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Published Papers (2 papers)

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12 pages, 1072 KiB  
Article
Connecting Gene Variation to Treatment Outcomes in Metastatic Castration-Resistant Prostate Adenocarcinoma: Insights into Second-Generation Androgen Receptor Axis-Targeted Therapies
by Ana Vaz-Ferreira, Valéria Tavares, Inês Guerra de Melo, Patrícia Rafaela Rodrigues, Ana Afonso, Maria Joaquina Maurício and Rui Medeiros
Int. J. Mol. Sci. 2024, 25(18), 9874; https://doi.org/10.3390/ijms25189874 - 12 Sep 2024
Viewed by 891
Abstract
Prostate cancer (PC) is one of the most commonly diagnosed tumours among men. Second-generation androgen receptor axis-targeted (ARAT) agents, namely abiraterone acetate (AbA) and enzalutamide (ENZ), are currently used in the management of metastatic castration-resistant PC (mCRPC). However, the treatment is challenging due [...] Read more.
Prostate cancer (PC) is one of the most commonly diagnosed tumours among men. Second-generation androgen receptor axis-targeted (ARAT) agents, namely abiraterone acetate (AbA) and enzalutamide (ENZ), are currently used in the management of metastatic castration-resistant PC (mCRPC). However, the treatment is challenging due to the lack of prognostic biomarkers. Meanwhile, single-nucleotide polymorphisms (SNPs) have emerged as potential prognostic indicators of mCRPC. Thus, this study evaluated the impact of relevant SNPs on the treatment outcomes of 123 mCRPC patients enrolled in a hospital-based cohort study. The CYP17A1 rs2486758 C allele was associated with a 50% reduction in the risk of developing castration resistance (hazard ratio (HR) = 0.55; p = 0.003). Among patients without metastasis at tumour diagnosis and under AbA, a marginal association between YBX1 rs10493112 and progression-free survival was detected (log-rank test, p = 0.056). In the same subgroup, significant associations of HSD3B1 rs1047303 (CC/CA vs. AA; HR = 3.41; p = 0.025), YBX1 rs12030724 (AT vs. AA; HR = 3.54; p = 0.039) and YBX1 rs10493112 (log-rank test, p = 0.041; CC vs. AA/AC; HR = 3.22; p = 0.053) with overall survival were also observed, which were confirmed by multivariate Cox analyses. Although validation with larger cohorts is required, these findings suggest that SNPs could enhance the prognosis assessment of mCRPC patients, leading to a more personalised treatment. Full article
(This article belongs to the Special Issue Recent Molecular Research in Virology and Oncology)
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22 pages, 4970 KiB  
Article
Viral Diversity in Samples of Freshwater Gastropods Benedictia baicalensis (Caenogastropoda: Benedictiidae) Revealed by Total RNA-Sequencing
by Tatyana V. Butina, Tamara I. Zemskaya, Artem N. Bondaryuk, Ivan S. Petrushin, Igor V. Khanaev, Ivan A. Nebesnykh and Yurij S. Bukin
Int. J. Mol. Sci. 2023, 24(23), 17022; https://doi.org/10.3390/ijms242317022 - 30 Nov 2023
Cited by 2 | Viewed by 1200
Abstract
Previously, the main studies were focused on viruses that cause disease in commercial and farmed shellfish and cause damage to food enterprises (for example, Ostreavirusostreidmalaco1, Aurivirus haliotidmalaco1 and Aquabirnavirus tellinae). Advances in high-throughput sequencing technologies have extended the studies to natural [...] Read more.
Previously, the main studies were focused on viruses that cause disease in commercial and farmed shellfish and cause damage to food enterprises (for example, Ostreavirusostreidmalaco1, Aurivirus haliotidmalaco1 and Aquabirnavirus tellinae). Advances in high-throughput sequencing technologies have extended the studies to natural populations of mollusks (and other invertebrates) as unexplored niches of viral diversity and possible sources of emerging diseases. These studies have revealed a huge diversity of mostly previously unknown viruses and filled gaps in the evolutionary history of viruses. In the present study, we estimated the viral diversity in samples of the Baikal endemic gastropod Benedictia baicalensis using metatranscriptomic analysis (total RNA-sequencing); we were able to identify a wide variety of RNA-containing viruses in four samples (pools) of mollusks collected at three stations of Lake Baikal. Most of the identified viral genomes (scaffolds) had only distant similarities to known viruses or (in most cases) to metagenome-assembled viral genomes from various natural samples (mollusks, crustaceans, insects and others) mainly from freshwater ecosystems. We were able to identify viruses similar to those previously identified in mollusks (in particular to the picornaviruses Biomphalaria virus 1 and Biomphalaria virus 3 from the freshwater gastropods); it is possible that picorna-like viruses (as well as a number of other identified viruses) are pathogenic for Baikal gastropods. Our results also suggested that Baikal mollusks, like other species, may bioaccumulate or serve as a reservoir for numerous viruses that infect a variety of organisms (including vertebrates). Full article
(This article belongs to the Special Issue Recent Molecular Research in Virology and Oncology)
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