Chronic Liver Disease and Hepatocellular Carcinoma—2nd Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 31 March 2025 | Viewed by 11
Special Issue Editors
Interests: chronic liver disease; hepatocellular carcinoma; liver metabolism
Special Issues, Collections and Topics in MDPI journals
2. NEST, Istituto Nanoscienze-CNR and Scuola Normale Superiore, Piazza San Silvestro 12, 56127 Pisa, Italy
Interests: pharmacology; molecular pharmacology; demyelination; neuroinflammation
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Chronic liver disease of different aetiologies, such as viral, metabolic-derived, or autoimmune pathologies, represents a major risk factor for the development of hepatocellular carcinoma (HCC). This primary liver malignancy has been the sixth most diagnosed cancer in 2020, and the third leading cause of cancer-related death worldwide. Due to high morbidity and mortality, as well as growing incidence, HCC represents a global health challenge. Since about 80% of patients develop HCC as consequence of chronic liver disease and cirrhosis, many studies are focusing on unravelling the molecular mechanisms responsible for its development and progression in order to find new therapeutic targets and predictive marker of its prognosis that could prevent the progression of chronic disease to cancer. Studies that focus on this topic are welcome in this Special Issue.
This Special Issue aims to provide new insights on novel molecular targets, therapeutic options, and/or biomarkers which could be helpful in preventing the progression of chronic liver disease to HCC and that could potentially be exploited in clinical development. Studies investigating naturally derived materials are also welcome, even though they must report a precise description of the active ingredients of the plant extract.
Dr. Daniela Gabbia
Dr. Sara Carpi
Guest Editors
Manuscript Submission Information
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Keywords
- hepatocellular carcinoma
- NAFLD/NASH
- viral hepatitis
- autoimmune liver disease
- immunotherapy
- biomarker
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