Advanced Research on Wound Healing 2.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 20 November 2024 | Viewed by 1691
Special Issue Editor
Interests: healthy promotion; wound healing; immune tolerance
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Wound healing after damage to the skin involves a complex interplay between many cellular players of the skin, primarily keratinocytes, fibroblasts, endothelial cells of vessels and recruited immune cells, and their associated extracellular matrix. Wound healing occurs through well-orchestrated phases of hemostasis, inflammation, proliferation, and tissue remodeling.
Before migrating forward, wound-edge keratinocytes must change their cell-to-matrix adhesions. As a response to injury, endothelial progenitor cells are driven to the site of injury to initiate angiogenesis. In turn, this is arbitrated by VEGF, which triggers the activation of endothelial nitric oxide synthase (eNOS). Angiogenesis is important for providing essential components to the wound, but several cytokines (PDGF, EGF, IGF-1, and IL-8) involved in accelerating angiogenesis are downregulated in chronic wounds. Thus, the imbalance of various cells and growth factors leads to the delayed wound healing response.
With the growth of microbiome 16S ribosomal RNA sequencing opportunities, it is now possible to survey the full microbial flora of wounds, and early datasets are revealing some common genera between diabetic and venous leg ulcers. Is there a microbiota that predicts healing outcome, and can the immune response in chronic wounds be reprogrammed to be better at killing wound pathogens?
Epigenetic modifications are required for cellular differentiation and growth, but abnormal changes result in a variety of diseases. It is becoming evident that epigenetics plays an important role in wound healing, and our understanding of epigenetic control in diabetes-related complications is still limited.
Dr. Rong-Fu Chen
Guest Editor
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Keywords
- molecular mechanism
- signal transduction
- microbiota
- DNA methylation
- histone modifications
- micro-RNAs
- circRNAs
- long noncoding RNA
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