Molecular Mechanisms of Ozone Therapy
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 20 January 2026 | Viewed by 934
Special Issue Editors
2. Fundación Canaria del Instituto de Investigación Sanitaria de Canarias (FIISC), Las Palmas, Spain
3. Instituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias, Universidad de La Laguna, Tenerife, Spain
4. CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, Madrid, Spain
Interests: ozone therapy; atherosclerosis; hypertension; lipoproteins; genomics
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2. Universitary Institute for Research in Biomedicine and Health (IUIBS), Molecular and Translational Pharmacology (BIOPHARM) Group, University of Las Palmas de Gran Canaria, Las Palmas, Spain
Interests: preclinical and clinical research (oncology, radiation therapy, chronic pain)
Special Issues, Collections and Topics in MDPI journals
Interests: free living amoebae; therapeutics; emerging parasitic protozoa; diagnosis; natural compounds; synthetic compounds
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue on Molecular Mechanisms of Ozone Therapy focuses on advancing the understanding of how medical ozone exerts its therapeutic effects beyond the well-established activation of the Nrf2 pathway. Ozone therapy has demonstrated benefits in modulating cellular redox balance, regulating mitochondrial function, and enhancing cellular signaling processes such as autophagy and apoptosis.
This Special Issue aims to describe lesser-known molecular mechanisms, including the role of ozone in modulating immune response, improving endothelial function, and influencing key transcription factors and signaling cascades like NF-κB, HIF-1α, and MAPKs. By highlighting these underexplored pathways, this Special Issue seeks to provide a comprehensive view of the cellular and molecular basis of ozone therapy, with its potential applications in managing conditions such as pain, chronic inflammation, ischemic syndromes, ischemia–reperfusion injury, and neurodegenerative disorders. We are open to expanding the areas of interest of this Special Issue to include potential in vivo and ex vivo mechanisms of action of ozone that are relevant to the management of infectious diseases, their complications, and/or pathogen control, with a particular focus on addressing antimicrobial resistance and emerging infectious diseases.
Dr. Francisco Rodríguez-Esparragón
Dr. Bernadino Clavo
Dr. Jacob Lorenzo-Morales
Guest Editors
Manuscript Submission Information
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Keywords
- antioxidant response
- cellular stress responses
- inflammatory signaling
- mitochondrial function
- molecular pathways
- Nrf2
- oxidative stress
- ozone therapy
- redox regulation
- antimicrobial resistance
- infectious diseases
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