Targeting Apoptotic Pathways in Cancer Therapy
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: closed (31 October 2024) | Viewed by 301
Special Issue Editor
Interests: apoptosis; caspase; cell cycle; cell proliferation; cytotoxicity; in vitro antiproliferative activity; mitogen-activated protein kinases; reactive oxygen species; structure–activity relationship
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Apoptosis is a form of regulated cell death that plays a major role in an array of physiological and pathophysiological conditions. Distinct and interconnected signaling pathways trigger the execution of apoptosis. Together with sustained proliferative signaling, resistance to apoptosis is recognized as one of the cellular hallmarks of cancer. Exponential progress in the regulation of death and survival signaling cascades has recently been achieved. This includes the executioners of apoptosis, B-cell lymphoma 2 family proteins, and oxidative stress. The new advances in this field will allow for the identification of new modulators of the pathways in cell death and survival. This knowledge may contribute to the preparation of therapeutic strategies of interest in medicine. It includes the ability to potentiate cytotoxicity against malignant cells or potential applications in other metabolic or immunological diseases.
This Special Issue aims to improve our understanding of the molecular mechanisms involved in apoptosis that may contribute to the efficacy of cancer therapies. Contributions may relate to the events triggered by different physical and chemical agents, including naturally occurring and synthetic compounds, and/or by physiological and pathophysiological conditions.
Prof. Dr. Francisco Estevez
Guest Editor
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Keywords
- apoptosis
- caspase
- cell cycle
- cytotoxicity
- reactive oxygen species
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