Targeting Apoptotic Pathways in Cancer Therapy
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: closed (31 October 2024) | Viewed by 322
Special Issue Editor
Interests: apoptosis; caspase; cell cycle; cell proliferation; cytotoxicity; in vitro antiproliferative activity; mitogen-activated protein kinases; reactive oxygen species; structure–activity relationship
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Apoptosis is a form of regulated cell death that plays a major role in an array of physiological and pathophysiological conditions. Distinct and interconnected signaling pathways trigger the execution of apoptosis. Together with sustained proliferative signaling, resistance to apoptosis is recognized as one of the cellular hallmarks of cancer. Exponential progress in the regulation of death and survival signaling cascades has recently been achieved. This includes the executioners of apoptosis, B-cell lymphoma 2 family proteins, and oxidative stress. The new advances in this field will allow for the identification of new modulators of the pathways in cell death and survival. This knowledge may contribute to the preparation of therapeutic strategies of interest in medicine. It includes the ability to potentiate cytotoxicity against malignant cells or potential applications in other metabolic or immunological diseases.
This Special Issue aims to improve our understanding of the molecular mechanisms involved in apoptosis that may contribute to the efficacy of cancer therapies. Contributions may relate to the events triggered by different physical and chemical agents, including naturally occurring and synthetic compounds, and/or by physiological and pathophysiological conditions.
Prof. Dr. Francisco Estevez
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- apoptosis
- caspase
- cell cycle
- cytotoxicity
- reactive oxygen species
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
