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Toxicity of Heavy Metal Compounds

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Toxicology".

Deadline for manuscript submissions: 30 August 2024 | Viewed by 855

Special Issue Editor


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Guest Editor
Helmholtz-Zentrum Dresden-Rossendorf, Institute of Resource Ecology, 01328 Dresden, Germany
Interests: heavy metal speciation in biosystems; lanthanides and actinides; spectroscopy; radiochemistry; radioecology

Special Issue Information

Dear Colleagues,

The use of heavy metals in industry, research, and medicine has increased rapidly over recent decades. However, from mining and industrial manufacturing to waste disposal, there is a potential risk of heavy metals being released into the environment. Contamination of the environment and finally incorporation of heavy metals into living organisms poses a potential health risk. The toxicity of heavy metals is influenced by various factors, e.g., binding form or oxidation state (generally, speciation). For a better understanding of the toxicity of heavy metals and for effective decontamination or decorporation strategies, knowledge of the speciation and reactions of heavy metals at the molecular and cellular level is essential.

In this Special Issue, reviews, original research articles, and communications covering chemical and analytical as well as biochemical and biological studies of the reactions of heavy metals or heavy metal compounds with biosystems (e.g., cells, organs, biofluids, or single bio-related molecules) are highly welcome. Contributions on related topics would also be much appreciated.

Dr. Astrid Barkleit
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • heavy metal
  • coordination
  • complexation
  • binding form
  • speciation
  • biomolecules
  • (cyto-) toxicity
  • cell death mechanism
  • spectroscopy
  • microscopy

Published Papers (1 paper)

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Research

18 pages, 3868 KiB  
Article
Integrating Transcriptomics and Proteomics to Characterize the Intestinal Responses to Cadmium Exposure Using a Piglet Model
by Yikun Li, Yiling Pan, Yulong Yin and Ruilin Huang
Int. J. Mol. Sci. 2024, 25(12), 6474; https://doi.org/10.3390/ijms25126474 - 12 Jun 2024
Viewed by 329
Abstract
Cadmium (Cd) is a heavy metal element with a wide range of hazards and severe biotoxicity. Since Cd can be easily accumulated in the edible parts of plants, the exposure of humans to Cd is mainly through the intake of Cd-contaminated food. However, [...] Read more.
Cadmium (Cd) is a heavy metal element with a wide range of hazards and severe biotoxicity. Since Cd can be easily accumulated in the edible parts of plants, the exposure of humans to Cd is mainly through the intake of Cd-contaminated food. However, the intestinal responses to Cd exposure are not completely characterized. Herein, we simulated laboratory and environmental Cd exposure by feeding the piglets with CdCl2-added rice and Cd-contaminated rice (Cdcr) contained diet, as piglets show anatomical and physiological similarities to humans. Subsequent analysis of the metal element concentrations showed that exposure to the two types of Cd significantly increased Cd levels in piglets. After verifying the expression of major Cd transporters by Western blots, multi-omics further expanded the possible transporters of Cd and found Cd exposure causes wide alterations in the metabolism of piglets. Of significance, CdCl2 and Cdcr exhibited different body distribution and metabolic rewiring, and Cdcr had stronger carcinogenic and diabetes-inducing potential. Together, our results indicate that CdCl2 had a significant difference compared with Cdcr, which has important implications for a more intense study of Cd toxicity. Full article
(This article belongs to the Special Issue Toxicity of Heavy Metal Compounds)
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