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Advances in Molecular Research of Kidney Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 20 March 2026 | Viewed by 1342

Special Issue Editor


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Guest Editor
Nephrology, Dialysis and Transplantation, ARNAS “Brotzu”, Cagliari, Italy
Interests: renal pathology; immune-mediated diseases; nephrology; onconephrology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue, "Advances in Molecular Research of Kidney Disease", aims to showcase the latest breakthroughs in understanding the molecular mechanisms underlying kidney diseases. We invite high-quality research that includes biomolecular experiments, focusing on novel insights into the pathophysiology, diagnosis, and treatment of kidney disorders. Areas of interest include molecular genetics, biomarkers, cellular signaling pathways, and innovative therapeutic approaches such as bioartificial kidneys, SGLT2 inhibitors, and targeted gene therapies. Clinical studies that incorporate molecular or biomolecular experiments are particularly welcome. By highlighting these advancements, we aim to advance our understanding of kidney disease and contribute to the development of more effective interventions, ultimately improving patient outcomes.

Dr. Andrea Angioi
Guest Editor

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Keywords

  • molecular genetics
  • kidney disease
  • biomarkers
  • cellular signaling
  • target therapeutics
  • innovative treatments

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Published Papers (1 paper)

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Research

19 pages, 1573 KB  
Article
Short-Term: Cellular Metabolism and Gene Expression During the Onset of Diabetic Kidney Disease: A Diabetes Mellitus Experimental Model
by Jéssica Encinas, Glaucia Veiga, Joyce Raimundo, Matheus Perez, Giuliana Petri, Renan Cavalheiro, Pedro Reis, Laura Maifrino, Beatriz Alves and Fernando Fonseca
Int. J. Mol. Sci. 2025, 26(19), 9676; https://doi.org/10.3390/ijms26199676 - 4 Oct 2025
Viewed by 419
Abstract
Diabetes is a chronic disease with a rising global prevalence. Research focuses on understanding its metabolic implications and early signaling of disease onset and complications, particularly the interconnected effects on the kidneys and brain. The objective of this study was to evaluate the [...] Read more.
Diabetes is a chronic disease with a rising global prevalence. Research focuses on understanding its metabolic implications and early signaling of disease onset and complications, particularly the interconnected effects on the kidneys and brain. The objective of this study was to evaluate the expression profile in the genes Mct1, Mct4, Cd147, Hif-1α and Vegf for different biological matrices in rats induced to diabetes in the determined periods of 7, 21, 30 and 40 days. Methods: Wistar rats (160–180g, n = 68), divided into sham and diabetic groups, were evaluated according to tissue samples from the brain and kidney, using classical biochemical analyses and assessing temporal intergroup differential gene expression by qPCR. Additionally, immunohistochemical analysis was performed on kidney samples to evaluate collagen deposition. In the renal tissues, we observed a decrease in the expression of Hif-1α (21 vs. 30 days) and Vegf (21 vs. 40 days), accompanied by an increase in collagen deposition. In the brain, alterations were observed in all evaluated genes when comparing the early group (7 days) to the later groups (30 and 40 days). We observed that the evaluated genes, as well as the collagen deposition analyzed by immunohistochemistry, are related to metabolic changes that, over time, contribute to the worsening of diabetes and the progression of secondary diseases directly and/or indirectly involving the studied tissues. Full article
(This article belongs to the Special Issue Advances in Molecular Research of Kidney Diseases)
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