Production of Bioactive Compounds by Microbes: Biosynthetic Pathway Elucidation and Metabolic Engineering
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".
Deadline for manuscript submissions: 30 June 2025 | Viewed by 22
Special Issue Editors
Interests: plant natural products; yeast; metabolic engineering; synthetic biology; environmental microbiota; gut microbiota; precise modulation
Special Issues, Collections and Topics in MDPI journals
Interests: hepatotoxicity; immune and inflammation
Special Issue Information
Dear Colleagues,
Microbes serve as potent cell factories for the production of bioactive compounds, which could be applied in medicine, agriculture, food, cosmetics, and various industries, often with the aid of engineering tools. The elucidation of biosynthetic pathways and the application of metabolic engineering are critical for achieving the efficient production of these valuable compounds. Pathway elucidation relies on genomic sequencing, gene annotation, and experimental validation to uncover the key enzymes driving the synthesis. Metabolic engineering leverages genetic manipulation, metabolic flux analysis, and the reprogramming of microbial metabolism to enhance the titer, rate, and yield of target bioactive compounds. These strategies have been successfully implemented to produce plant-derived and microbial natural products, specialty chemicals, and biofuels. With continued advancements in synthetic biology, machine learning, and high-throughput screening, the microbial production of bioactive compounds is becoming increasingly efficient and scalable, unlocking new industrial opportunities.
This Special Issue is supervised by Dr. Yongjun Wei, Dr. Ziqiao Yuan and Dr. Ying Zhang, assisted by our Guest Editor’s assistant editor Dr. Xiaoling Zhang (Zhengzhou University).
Dr. Yongjun Wei
Dr. Ziqiao Yuan
Dr. Ying Zhang
Guest Editors
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Keywords
- bioacitve compounds
- engineered microbes
- biosynthetic pathway
- metabolic engineering
- synthetic biology
- metabolic reprogramming
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