Molecular Pathways Connecting Body Fat and Cancer
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: closed (28 February 2021) | Viewed by 6090
Special Issue Editor
Interests: adipokines and cancer; cancer and Alzheimer’s disease; cancer; obesity and diet
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Obesity is a worsening public health problem worldwide. Excess body fat increases the risk of cancer, heart disease, diabetes, and Alzheimer’s disease, but the mechanisms for this increase are not fully known. Recent interest has focused on the role of fat-produced adipokines, including leptin and adiponectin, but specific effects of many others remain largely unexplored. Leptin is involved in many cellular processes, including apoptosis, angiogenesis, and inflammation, while adiponectin in some aspects counters these effects. Molecularly, these adipokines influence many important signaling pathways, including p53, Notch, Wnt, and others. The basic and clinical importance of these actions in disease require further investigation.
This Special Issue will mainly focus on the molecular activity of adipokines in cancer. Cell signaling in both proliferative and suppressive directions will be covered. New areas of molecular activity by lesser-known adipokines will be addressed. Further exploration of how fat is involved in cancer and other diseases should be stimulated, with new evidence-based disease prevention research to follow.
Dr. Daniel W. Nixon
Guest Editor
Manuscript Submission Information
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Keywords
- obesity
- body fat
- cancer
- adipokines
- leptin
- adiponectin
- angiogenesis
- molecular activity
- signaling pathways