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Research Progress in RNA-Binding Proteins 2.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 3986

Special Issue Editor


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Guest Editor
1. UMR7156—Génétique Moléculaire, Génomique, Microbiologie (GMGM), University of Strasbourg, CNRS, 67000 Strasbourg, France
2. University of Strasbourg Institute for Advanced Study (USIAS), University of Strasbourg, 67000 Strasbourg, France
Interests: RNA-binding proteins; noncoding RNA; ribonucleoproteins; interactomics; ribosome biogenesis; bacteria; mitochondria
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Special Issue Information

Dear Colleagues,

RNA-binding proteins (RBPs) are omnipresent in biology. Makers, breakers, modifiers, and sensors of RNAs unavoidably shift into the research focus in fields as different as molecular and cell biology, molecular genetics, infection and immunity, synthetic biology, and molecular medicine. They are also fascinating molecular objects with a stunning diversity of structures, RNA recognition modes, and activities. Standalone players or members of exuberant ribonucleoproteins, RBPs secure key housekeeping functions while also featuring in a number of accessory and regulatory roles. The last decade has seen a flurry of studies unravelling the genuine scope of RBP-mediated processes and molecular mechanisms. This Special Issue focuses on emerging molecular aspects of RBP biology and the new methods to approach them. This includes but is not limited to recent progress in the prediction, identification, structural characterization, and measurement of RNA–protein interactions, the biochemical behavior and activities of RBPs, novel and classical RBP classes, phase-separation and formation of biocondensates, RBP evolution, and design.

Dr. Alexandre Smirnov
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • RNA-binding protein
  • RNA-protein interaction
  • ribonucleoprotein
  • RNA-protein complex
  • recognition
  • RNA metabolism
  • condensate
  • molecular evolution
  • protein design

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Published Papers (2 papers)

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Editorial

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4 pages, 505 KiB  
Editorial
Research Progress in RNA-Binding Proteins
by Alexandre Smirnov
Int. J. Mol. Sci. 2023, 24(1), 58; https://doi.org/10.3390/ijms24010058 - 21 Dec 2022
Cited by 2 | Viewed by 1680
Abstract
RNA-binding proteins are everywhere and accompany RNA molecules at every stage of their molecular life, from “birth” (transcription) through “growing up” (maturation), “active life” (molecular function) until “death” (turnover) [...] Full article
(This article belongs to the Special Issue Research Progress in RNA-Binding Proteins 2.0)
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Research

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15 pages, 3876 KiB  
Article
NMR Analysis Suggests Synergy between the RRM2 and the Carboxy-Terminal Segment of Human La Protein in the Recognition and Interaction with HCV IRES
by Aikaterini I. Argyriou, Georgios A. Machaliotis, Garyfallia I. Makrynitsa, Eleni G. Kaliatsi, Constantinos Stathopoulos and Georgios A. Spyroulias
Int. J. Mol. Sci. 2023, 24(3), 2572; https://doi.org/10.3390/ijms24032572 - 29 Jan 2023
Cited by 1 | Viewed by 1841
Abstract
The La protein (lupus antigen) is a ubiquitous RNA-binding protein found in all human cells. It is mainly localized in the nucleus, associates with all RNA polymerase III (Pol III) transcripts, as the first factor they interact with, and modulates subsequent processing events. [...] Read more.
The La protein (lupus antigen) is a ubiquitous RNA-binding protein found in all human cells. It is mainly localized in the nucleus, associates with all RNA polymerase III (Pol III) transcripts, as the first factor they interact with, and modulates subsequent processing events. Export of La to the cytoplasm has been reported to stimulate the decoding of specific cellular and viral mRNAs through IRES-dependent (Internal ribosome entry site) binding and translation. Using NMR (Nuclear Magnetic Resonance) spectroscopy, we provide atomic-level-resolution structural insights on the dynamical properties of human La (hLa) protein in solution. Moreover, using a combination of NMR spectroscopy and isothermal titration calorimetry (ITC), we provide evidence about the role and ligand specificity of the C-terminal domain of the La protein (RRM2 and C-terminal region) that could mediate the recognition of HCV-IRES. Full article
(This article belongs to the Special Issue Research Progress in RNA-Binding Proteins 2.0)
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