Identification of Host Factors Involved in Pathogenic Mechanisms of Infectious Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: closed (30 September 2022) | Viewed by 5320
Special Issue Editor
Interests: severe malaria; infectious diseases; genetic susceptibility/resistance; transcriptomics; genomics; regulatory variants; coding variants; markers of severity
Special Issue Information
Dear Colleagues,
Infectious diseases are a major cause of human morbidity and mortality in all regions of the world and are of particular concern in the context of the COVID-19 pandemic. Among infected individuals, a fraction develop severe disease while others remain asymptomatic. This inter-individual variability is due to several environmental, pathogen and host factors. This special issue is devoted to the identification of host factors involved in susceptibility/resistance to infectious diseases. Despite major advances, the pathogenic mechanisms are still unclear. Detailed molecular mechanisms must be discovered to understand why, in some cases, the host’s immune system is compromised. This is a challenge that would lead to improved diagnosis and treatment and thus to better clinical management. We invite researchers to submit research articles, reviews and comments on topics of interest including, but not limited to, those describe below:
- Identification of genetic factors through genome-wide association study (GWAS), case-control studies, linkage analysis, exome sequencing, targeting sequencing;
- Functional characterization of regulatory variants associated with infection or disease using, for example, bioinformatic SNPs prioritization, reporter gene assays, and CRISPR-Cas9 technology;
- Transcriptomic approaches and enrichment analysis to identify deregulated genes, lncRNAs or miRNAs deregulated in infectious diseases and pathogenic pathways;
- Investigate epigenomic and transcriptional cooperation to elucidate networks in infectious disease which is necessary for the design of targeted therapies;
- Selection of biomarkers that can be used as predictive and prognostic markers for prevention and medical care;
- Use of an animal model to decipher pathogenic processes.
Dr. Sandrine Marquet
Guest Editor
Manuscript Submission Information
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Keywords
- Infectious disease
- Malaria
- COVID-19
- susceptibility gene
- transcriptome
- regulatory variant
- coding variant
- pathogenic pathways
- epigenomic factor
- biomarkers
