Chitosan-Based Nanoparticles
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".
Deadline for manuscript submissions: closed (25 June 2019) | Viewed by 53601
Special Issue Editors
Interests: controlled drug delivery systems; nanomedicine; nutraceutical products; thermosensitive hydrogels; ocular delivery; oral delivery; multifunctional chitosan derivatives; mucoadhesive nanoparticles
Special Issues, Collections and Topics in MDPI journals
Interests: mucoadhesive polymeric nanoparticulate systems; ocular and oral administration of drugs; nutraceutic; delivery systems of nutraceutical products; thermosensitive hydrogels; chitosan and its derivatives
Special Issues, Collections and Topics in MDPI journals
Interests: nanomedicine; drug delivery; pharmaceutics and pharmaceutical technology; polymeric biomaterials; biodegradable polymers
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
It is known that even slight physicochemical differences on the nanoparticle surface are reflected in significant biological differences concerning, e.g., cellular uptake, the biological processes regulating such an uptake, and nanoparticle biodistribution. Together with the surface features, nanoparticle size and shape are also known to affect cellular uptake and particle biodistribution. It appears thus to be promising to more deeply investigate and correlate these aspects to be able to modulate and promote selective cellular uptake, thus targeting the site of action, resulting in strong pharmacological activity with low systemic exposure.
Much interest has been focused on nanoparticulate release systems based on chitosan and its derivatives because of their good biocompatibility and effectiveness in releasing macromolecular drugs. The physicochemical surface properties of the nanoparticles based on chitosan conjugates depend on the functional groups that have been substituted on the polymer chains. The use of chitosan and its derivatives for the preparation of medicated nanoparticles will be the focus of the present Special Issue to derive some considerations regarding the structure–activity relationship.
Prof. Dr. Ylenia Zambito
Dr. Angela Fabiano
Dr. Anna Maria Piras
Guest Editors
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Keywords
- Chitosan derivatives
- Nanoparticulate drug delivery systems
- Macromolecular drugs
- Mucoadhesive nanoparticles
- Mucopenetrating nanoparticles
- Cells uptake
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