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Chromatin Remodeling and Its Regulation by Small Molecules

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biophysics".

Deadline for manuscript submissions: closed (30 June 2020) | Viewed by 3853

Special Issue Editor


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Guest Editor
Research Director at CNRS, University of Lille, Unité de Glycobiologie Structurale et Fonctionnelle, CNRS UMR8576, 59000 Lille, France
Interests: gene regulation; chromatin remodeling; macromolecular electrostatics; statistical physics of biomolecular recognition

Special Issue Information

Dear Colleagues,

Chromatin remodeling is a key fundamental mechanism in gene control and chromatin maintenance, such as the activation or repression of transcription and DNA repair. Its deregulation is increasingly appreciated as being important for the development of cancer. Post-translational modifications play a decisive role in remodeler regulation, by either furnishing regulatory signals for mechanical processes such as the displacement or removal of nucleosomes or by providing epigenetic markers. Since chromatin remodelers in complex with nucleosomes provide numerous putative interaction surfaces, there is an emerging literature on the role of small molecules in intervening and co-regulating chromatin remodeling. This Special Issue aims to bring together research results in this important field. We are particularly interested in receiving papers that incorporate different approaches; exemplary cases, by no means exclusive, are listed in the keywords. 

Dr. Ralf Blossey
Guest Editor

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Keywords

  • Bromodomain inhibitors
  • Antisense RNA
  • Aptamers
  • Histone deacetylase inhibitors
  • DNA-methyltransferase inhibitors
  • Peptide inhibitors
  • Small-molecule inhibitors

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Published Papers (1 paper)

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Review

11 pages, 850 KiB  
Review
Replication-Coupled Chromatin Remodeling: An Overview of Disassembly and Assembly of Chromatin during Replication
by Céline Duc and Christophe Thiriet
Int. J. Mol. Sci. 2021, 22(3), 1113; https://doi.org/10.3390/ijms22031113 - 23 Jan 2021
Cited by 5 | Viewed by 3518
Abstract
The doubling of genomic DNA during the S-phase of the cell cycle involves the global remodeling of chromatin at replication forks. The present review focuses on the eviction of nucleosomes in front of the replication forks to facilitate the passage of replication machinery [...] Read more.
The doubling of genomic DNA during the S-phase of the cell cycle involves the global remodeling of chromatin at replication forks. The present review focuses on the eviction of nucleosomes in front of the replication forks to facilitate the passage of replication machinery and the mechanism of replication-coupled chromatin assembly behind the replication forks. The recycling of parental histones as well as the nuclear import and the assembly of newly synthesized histones are also discussed with regard to the epigenetic inheritance. Full article
(This article belongs to the Special Issue Chromatin Remodeling and Its Regulation by Small Molecules)
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