Endocannabinoid Receptors in Human Health and Disease, 2nd Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".
Deadline for manuscript submissions: 10 December 2024 | Viewed by 50
Special Issue Editor
Interests: cannabinoids/endocannabinoids and related bioactive lipids; obesity; metabolism; adipogenesis; lipid and glucose metabolism
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
While endocannabinoids (N-arachidonoylethanolamine; AEA and 2-arachidonoyl glycerol; 2-AG) were initially found to activate the cannabinoid receptors CB1 and CB2, it is now understood that they bind to and modulate the activity of several different classes of receptors, including G protein-coupled receptors, transient receptor potential channels, and nuclear receptors. Additionally, AEA and 2-AG are now viewed as the canonical ligands of a broader family of bioactive lipids that constitute the endocannabinoidome, including many N-acylamines and 2-monoacyl glycerols. Despite their structural similarities to AEA and 2-AG, these ligands often display distinct (and sometimes opposing) receptor activity profiles to endocannabinoids. Research into this growing family, their receptor activity profiles, pharmacology, and involvement in regulating various physiological and pathological processes is still in its infancy. However, it is becoming clear that these bioactive lipids play important roles relevant to several disease states. This Special Issue aims to highlight recent advances in our understanding of the function of endocannabinoid-related receptors in physiological processes and diseases at CB1, CB2, and beyond to the many other receptors that comprise the wide endogenous cannabinoid system.
Suitable topics include but are not limited to ligand–receptor interactions and modeling, signal transduction, physiological activity, and altered activity within disease states. Due to the success of Volume I, we reopen it as Volume II, and seek your contribution to this significant topic.
Dr. Cristoforo Silvestri
Guest Editor
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Keywords
- endocannaibnoid
- cannabinoid
- receptors
- GPCR
- TRP channels
- nuclear receptors
- PPARS
- physiology
- pathophysiology
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