ijms-logo

Journal Browser

Journal Browser

Epigenetic Regulation in Immune Cells

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: closed (30 September 2020) | Viewed by 3863

Special Issue Editors


E-Mail
Guest Editor
The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia

E-Mail
Guest Editor
The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia

Special Issue Information

Dear Colleagues,

Over the past two decades, epigenetics research has exploded from being a disparate collection of biological phenomena to a fully-fledged and enthusiastically studied field. In more recent years, the field has expanded beyond studies of DNA methylation and post-translational modifications of histones to include DNA accessibility and three-dimensional genome organisation, among others.

In this Special Issue, we welcome original articles or reviews focusing on the role of epigenetics in immune cell function and differentiation. These cells are of particular interest as they have both diverse and well-understood functions, but also differentiate from a common progenitor along well-defined developmental pathways. Thus, immune lineages provide a perfect system to study natural epigenetic processes, as well as the consequences of artificial epigenetic modulation.

Dr. Christine Keenan
Dr. Timothy M. Johanson
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • epigenetics
  • histones
  • methylation
  • acetylation
  • genome organisation
  • immune cell function
  • immune cell differentiation

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

16 pages, 2246 KiB  
Article
The Probiotic BB12 Induces MicroRNAs Involved in Antigen Processing and Presentation in Porcine Monocyte-Derived Dendritic Cells
by Marlene Bravo-Parra, Marina Arenas-Padilla, Valeria Bárcenas-Preciado, Jesús Hernández and Verónica Mata-Haro
Int. J. Mol. Sci. 2020, 21(3), 687; https://doi.org/10.3390/ijms21030687 - 21 Jan 2020
Cited by 4 | Viewed by 3629
Abstract
MicroRNAs (miRNAs) mediate the regulation of gene expression. Several reports indicate that probiotics induce miRNA-mediated immunomodulation at different levels, such as cytokine production and the up-regulation of several markers related to antigen presentation in antigen-presenting cells. The objective of this work was to [...] Read more.
MicroRNAs (miRNAs) mediate the regulation of gene expression. Several reports indicate that probiotics induce miRNA-mediated immunomodulation at different levels, such as cytokine production and the up-regulation of several markers related to antigen presentation in antigen-presenting cells. The objective of this work was to identify target genes of miRNAs that are involved in the processing and presentation of antigens in monocyte-derived dendritic cells (moDCs) stimulated with the probiotic Bifidobacterium animalis ssp. lactis BB12 (BB12). First, an in silico prediction analysis for a putative miRNA binding site within a given mRNA target was performed using RNAHybrid software with mature sequences of differentially expressed miRNAs retrieved from a Genbank data set that included BB12-stimulated and unstimulated porcine monocytes. From them, 23 genes resulted in targets of 19 miRNAs, highlighting miR-30b-3p, miR-671-5p, and miR-9858-5p, whose targets were costimulatory molecules, and were overexpressed (p < 0.05) in BB12-stimulated moDCs. The analysis of moDCs showed that the percentage of cells expressing SLA-DR+CD80+ decreased significantly (p = 0.0081) in BB12-stimulated moDCs; interleukin (IL)-10 production was unchanged at 6 h but increased after 24 h of culture in the presence of BB12 (p < 0.001). In summary, our results suggest that SLA-DR and CD80 can be down-regulated by miRNAs miR-30b-3p, miR-671-5p, and miR-9858-5p, while miR-671-5p targets IL-10. Full article
(This article belongs to the Special Issue Epigenetic Regulation in Immune Cells)
Show Figures

Graphical abstract

Back to TopTop