Frontiers in Glioma Pathobiology
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: closed (15 November 2022) | Viewed by 3016
Special Issue Editor
Interests: brain tumors; glioblastoma; diffuse midline glioma; genomics and molecular classification; signaling pathways; PTEN tumor suppressor; NHERF1; diagnostic markers; therapy targets; glioma epidemiology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Glioblastoma is a high-grade diffuse glioma and the most frequent primary intraparenchymal brain tumor. To this day, treatment is a challenge and survival relatively poor. Therapy resistance stems from the pathobiological characteristics of diffuse gliomas, starting from the sanctuary generated by the blood–brain barrier preventing drug and immune cell cytotoxicity to resistance to radiotherapy due to genetic, epigenetic, DNA damage response and signal transduction mechanisms, cancer cell invasiveness and interaction with the microenvironment, and tumor heterogeneity and reprogramming. It is now clear that the understanding of the mechanisms of glioma initiation and progression is key to effective treatment development. In this Special Edition, experts in the field are invited to share a brief overview of the current knowledge on diffuse glioma pathobiology, as well as to highlight their forefront research findings and propose actionable biological and molecular vulnerabilities for these tumors deriving from their own research.
Dr. Maria-Magdalena Georgescu
Guest Editor
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Keywords
- diffuse glioma/glioblastoma/diffuse astrocytoma/oligodendroglioma/diffuse midline glioma
- tumor initiation/cells of origin
- genetics/somatic and germline
- cell cycle/DNA damage response
- epigenetic control/telomere maintenance
- growth signaling pathways/metabolism
- tumor heterogeneity
- invasiveness/microenvironment/angiogenesis/immune response
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