The Gas6/TAM System at the Crossroads of Inflammation and Fibrosis
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 3129
Special Issue Editor
Interests: multiple sclerosis; autoimmune diseases; anti-rheumatic drug therapy; osteoporosis; hypovitaminosis D; chronic inflammatory demyelinating polyneuropathy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Following the growth of scientific evidence over several years, it has been confirmed that Growth Arrest Specific Gene 6 (Gas6), the ligand of three tyrosine kinase receptors (TAMs) named Axl, Tyro3, and Mer, is deeply involved in the modulation of inflammation in human acute and chronic diseases as well as in tissue repair processes and fibrosis development. Therefore, an alteration of the GAS6/TAM system has been reported in autoimmune chronic diseases, in acute inflammatory diseases, and in chronic fibrotic diseases. This system is consistently a key regulator of the immune system (innate immunity in particular) and of damaged tissue repair. In addition, either Gas6 or the soluble form of TAM receptors (sTAMs) are circulating plasma proteins and are potentially useful as disease biomarkers. This Special Issue will offer a deep insight into the most recent data regarding the Gas6/TAM system and into new evidence of its action, which are relevant topics in translational research from bench to bedside for inflammation- and fibrosis-related diseases. Both reviews and original data are welcome. Potential topics include, but are not limited to:
- The Gas6/TAM system and the molecular basis of the modulation of inflammation, tissue repair of fibrosis initiation, or maintenance;
- The Gas6/TAM system and chronic diseases with fibrotic evolution (i.e., hepatic cirrhosis, systemic sclerosis, etc...);
- The Gas6/TAM system and neuroinflammation;
- The Gas6/TAM system and autoimmune diseases;
- The Gas6/TAM system and acute inflammation, including infections;
- The Gas6/TAM system and COVID-19;
- The Gas6/TAM system and cancer.
Dr. Pier Paolo Sainaghi
Guest Editor
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Keywords
- Growth Arrest Specific Gene 6 (Gas6)
- Axl
- Tyro3
- Mer tyrosine kinase receptors (TAM)
- inflammation
- fibrosis
