Advances in Lipid-Mediated Inflammation-Resolution Mechanisms in Health and Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: closed (31 October 2021) | Viewed by 8889
Special Issue Editors
Interests: bioactive lipids; specialized proresolving lipid mediators (SPMs); multiple sclerosis (MS); neuroscience; brain barriers; lipidomics; resolution of neuroinflammation
2. Laboratory of Resolution of Neuroinflammation, European Center for Brain Research (CERC)/IRCCS Santa Lucia Foundation, 00143 Rome, Italy
Interests: bioactive lipids; specialized proresolving lipid mediators (SPMs); immunology; innate and adaptive immunity; neuroinflammation; glial cells; multiple sclerosis (MS)
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Special Issue Information
Dear Colleagues,
The acute inflammatory response is host protective and initiated by tissue injury, infection, or exogenous stimuli. During acute inflammation, innate immune cells are recruited to the damaged or infected site and rapidly generate eicosanoids, which are responsible for the so-called “cardinal signs” of inflammation (redness, heat, swelling, pain, and loss of function). This needs to be self-limiting and promptly extinguished upon cessation or elimination of the noxious stimulus. This last process is an active process and is referred to as “resolution of inflammation”, during which immune cells undergo a temporal lipid mediator class switch and start producing specialized proresolving mediators (SPMs). An efficient resolution response is crucial to avoid tissue damage and to drive the restoration of full tissue homeostasis. In turn, uncontrolled or unresolved inflammation is an underlying cause of many chronic diseases and suggests that the resolution response is not functioning properly. Researchers in this field have done an amazing job over recent years, providing astonishing new insights into understanding the complex and coordinated processes that regulate the diverse inflammatory responses and the identification of several classes of resolution-inducing mediators as well as uncovering potential resolution defects in numerous chronic inflammatory diseases.
In this Special Issue, we will focus on the advances in the field of resolution-inducing mediators over the last 10 years, their impact on our overall understanding of resolution of inflammation and how alterations in this protective system aid the development of chronic inflammation in a wide variety of diseases, thereby positioning such mediators as novel therapeutics. We are seeking novel research articles in the field of inflammation-resolution or review articles focused on the topics shown in the keywords below that are dedicated to the developments of the last 10 years and how these have changed and/or enhanced our understanding of proinflammatory/proresolving lipid mediators in various inflammatory diseases. Our aim for this Special Issue is to shine a light on multidisciplinary research that examines how resolution-inducing lipid mediators can be eventually exploited as novel diagnostic and/or therapeutic opportunities to prevent chronic inflammatory diseases.
Dr. Gijs Kooij
Dr. Valerio Chiurchiù
Guest Editors
Manuscript Submission Information
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Keywords
- bioactive lipids (eicosanoids, sphingolipids, ceramides, endocannabinoids)
- specialized proresolving lipid mediators (SPMs)
- PUFA (omega 3 and omega 6)
- lipidomics
- metabolomics
- lipid biology (biosynthesis, degradation, transport, receptors and signalling)
- inflammation
- immunity (innate and adaptive)
- resolution of inflammation
- tissue homeostasis
- chronic inflammation
- low grade inflammation
- inflammatory diseases (metabolic, cardiovascular, pulmonary, gastrointestinal, autoimmune, cancer, neurodegenerative)
- noncommunicable diseases
- resolution pharmacology
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