Liver Cirrhosis and Hepatocellular Carcinoma: Pathogenesis, Diagnosis and Treatment
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (30 September 2019) | Viewed by 52834
Special Issue Editor
Interests: liver cirrhosis; hepatocellular carcinoma; non-coding RNAs; miRNAs; inflammation; biomarker; personalized cancer medicine
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Liver cirrhosis and hepatocellular carcinoma (HCC) represent the end-stage of most chronic liver diseases and are a major global health burden. Despite the enormous relevance of cirrhotic disease, pharmacological strategies for preventing the sequence leading from chronic hepatitis to liver cirrhosis and finally to HCC are still limited. Increasingly, liver cirrhosis is seen not as a single disease entity, but as one that can be subclassified into distinct molecular, etiological and clinical stages, with one-year mortality ranging from 1% to 57% depending on the disease stage. The assessment of the histological, biochemical and molecular patterns that characterizes liver cirrhosis and the understanding of the complex pathogenetic events/factors involved in the progression into HCC represent an exciting challenge. Moreover the characterization of biomarkers allowing the prediction of the individual risk of disease progression or to provide personalized treatment and/or prevention strategies still represents an unmet need. The aim of this Special Issue is to stimulate research allowing a better understanding of the pathogenesis of liver cirrhosis and HCC and its impact on disease management.
Dr. Christoph Roderburg
Guest Editor
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Keywords
- Pathogenesis of liver cirrhosis
- Pathogenesis of hepatocellular carcinoma
- Inflammation
- Epigenetics
- Non-coding RNAs
- Diagnosis and treatment
- Biomarkers
- Metabolomics
- Personalized medicine
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