Group I Metabotropic Glutamate Receptors: Physiological and Pathological Roles
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: closed (30 November 2021) | Viewed by 5409
Special Issue Editors
Interests: neurophysiology; neuropharmacology; neurotransmission; synaptic plasticity; dopaminergic system; mGluRI; neuregulins; neuropsychiatric disorders; Parkinson's disease
Special Issue Information
Dear Colleagues,
Group I metabotropic glutamate receptors (mGluRI), including mGluR1 and mGluR5 subtypes, are Gq/11-coupled receptors with a widespread expression in the brain. mGluRI are essential for proper brain functioning: they affect neuronal excitability, neurotransmission and synaptic plasticity, thus directly mediating cellular mechanisms underlying learning and memory processes and complex behaviors. Moreover, unbalanced mGluRI-dependent mechanisms have been reported in several neurological and psychiatric illnesses.
The aim of this Special Issue is to collect original papers and reviews to feature recent advances on mGluRI-dependent effects in health and brain diseases. Specifically, manuscripts will be accepted that describe mGluRI signaling and interactome (scaffolding proteins, regulatory proteins and signaling effectors, or mGluRI assembly with other receptors/ion channels), mGluRI functions in neurons and glial cells, their roles in the regulation of synaptic plasticity, learning and memory processes and complex behaviors, both in physiological and pathological conditions, also including neurodevelopmental disorders, neurodegenerative diseases, and psychopathologies.
Dr. Ada Ledonne
Prof. Dr. Nicola Mercuri
Guest Editors
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Keywords
- mGluR1
- mGluR5
- mGluRI signaling
- neurotransmission
- synaptic plasticity
- learning and memory
- behavior
- neurodevelopmental diseases
- neurological and psychiatric disorders
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