Microbial Genomics and Biosynthesis
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: closed (20 January 2023) | Viewed by 7832
Special Issue Editor
Interests: biosynthesis; antibiotics; gene regulation; non-coding RNA; streptomyces; strain prioritization; genetic engineering
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Microbial small molecules often have potent biological activities, e.g., anti-infective, anticancer, immunosuppressive activities, and mediator substances during microbe–microbe or host–microbe interactions. The increasing number of genome sequences has virtually advanced any microbial research area, including (i) the discovery of novel biosynthetic gene clusters and their products, (ii) new biosynthetic pathways and enzymatic mechanism, intricate and fascinating regulatory elements, (iii) novel mechanisms of resistance to anti-infectives, (iv) new approaches to the yield improvement of microbial products, and (v) microbial ecology.
Published genomes have also opened the door to strain prioritization. Researchers were previously limited to one or two strains for biosynthetic studies. Now, alternative strains can be found by genomic comparative analysis and be further investigated to establish a better model system. Interestingly, we could look for a better system in nature (by strain isolation, screening, and genome sequencing). Coupled with the continuous development of bioinformatic tools and biosynthetic knowledge, strain prioritization is on an upward trajectory to the discovery of molecular analogues with more potent bioactivities and/or more stable during isolation.
To contribute to the research areas mentioned above, this Special Issue will cover (but not be limited to) the following topics:
- Novel microbial strains as producers of bioactive small molecules;
- Microbial genomes as a source of inspiration in synthetic biology;
- Hidden treasures of molecular sciences unveiled by genome mining;
- Method development in genome sequencing and analysis;
- Microbial genomes as an essential tool for microbe–microbe or host–microbe interaction studies.
We look forward to your manuscript submission in the form of original research articles or reviews.
Dr. Hindra Hindra
Guest Editor
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
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Keywords
- secondary metabolism
- biosynthetic genes
- phylogenetic
- fermentation
- titer or yield
- specialized metabolites
- signaling molecules
- long-read sequencing
- heterologous expression
- induction/stimulation/activation
