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Neuroinflammatory Processes in Organ Homeostasis and Disease
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Neuroinflammatory Processes in Organ Homeostasis and Disease

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: closed (30 April 2022) | Viewed by 16257

Special Issue Editor

Dr. Laura Calvillo

E-Mail Website
Guest Editor
Cardiology Research Laboratory, Department of Cardiology, Istituto Auxologico Italiano, IRCCS, 20145 Milan, Italy
Interests: cardiovascular research; neuroinflammation; experimental models; 3R research; bioreactors; quantum biology; laboratory animal science
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Chronic conditions requiring long-term rehabilitation therapies, such as cardiovascular or metabolic disease, neurological disorder, or cancer, involve complex interactions between various systems/organs of the body and mutual influences, thus implicating a multiorgan approach. The morbidity and healthcare costs associated with chronic conditions impact both quality of life and health care costs. While a great deal of effort has been dedicated to understanding the pathogenesis and to finding therapies for individual pathologies, a multiorgan approach through the study of the crosstalk among systems is just beginning. Substantial evidence clearly suggests the existence of such a reciprocal neuro-immune-circulatory-network communication, but there are some gaps to fill.

This issue of the International Journal of Molecular Sciences will focus on “Neuroinflammatory Processes in Organ Homeostasis and Disease”, including new insights from in-vitro, ex-vivo, and in vivo experimental approaches. The challenge is to decode the neuro-immune crosstalk between organs to find new therapies.

Dr. Laura Calvillo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • immunity
  • microglia
  • autonomic nervous system
  • metabolism
  • cardiovascular system
  • pathology
  • neuropeptides
  • inflammation

Published Papers (2 papers)

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Review

15 pages, 999 KiB  
Review
The Interplay between Autonomic Nervous System and Inflammation across Systemic Autoimmune Diseases
by Chiara Bellocchi, Angelica Carandina, Beatrice Montinaro, Elena Targetti, Ludovico Furlan, Gabriel Dias Rodrigues, Eleonora Tobaldini and Nicola Montano
Int. J. Mol. Sci. 2022, 23(5), 2449; https://doi.org/10.3390/ijms23052449 - 23 Feb 2022
Cited by 36 | Viewed by 11164
Abstract
The autonomic nervous system (ANS) and the immune system are deeply interrelated. The ANS regulates both innate and adaptive immunity through the sympathetic and parasympathetic branches, and an imbalance in this system can determine an altered inflammatory response as typically observed in chronic [...] Read more.
The autonomic nervous system (ANS) and the immune system are deeply interrelated. The ANS regulates both innate and adaptive immunity through the sympathetic and parasympathetic branches, and an imbalance in this system can determine an altered inflammatory response as typically observed in chronic conditions such as systemic autoimmune diseases. Rheumatoid arthritis, systemic lupus erythematosus, and systemic sclerosis all show a dysfunction of the ANS that is mutually related to the increase in inflammation and cardiovascular risk. Moreover, an interaction between ANS and the gut microbiota has direct effects on inflammation homeostasis. Recently vagal stimulation techniques have emerged as an unprecedented possibility to reduce ANS dysfunction, especially in chronic diseases characterized by pain and a decreased quality of life as well as in chronic inflammation. Full article
(This article belongs to the Special Issue Neuroinflammatory Processes in Organ Homeostasis and Disease)
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14 pages, 611 KiB  
Review
Infection-Associated Mechanisms of Neuro-Inflammation and Neuro-Immune Crosstalk in Chronic Respiratory Diseases
by Belinda Camp, Sabine Stegemann-Koniszewski and Jens Schreiber
Int. J. Mol. Sci. 2021, 22(11), 5699; https://doi.org/10.3390/ijms22115699 - 27 May 2021
Cited by 10 | Viewed by 4292
Abstract
Chronic obstructive airway diseases are characterized by airflow obstruction and airflow limitation as well as chronic airway inflammation. Especially bronchial asthma and chronic obstructive pulmonary disease (COPD) cause considerable morbidity and mortality worldwide, can be difficult to treat, and ultimately lack cures. While [...] Read more.
Chronic obstructive airway diseases are characterized by airflow obstruction and airflow limitation as well as chronic airway inflammation. Especially bronchial asthma and chronic obstructive pulmonary disease (COPD) cause considerable morbidity and mortality worldwide, can be difficult to treat, and ultimately lack cures. While there are substantial knowledge gaps with respect to disease pathophysiology, our awareness of the role of neurological and neuro-immunological processes in the development of symptoms, the progression, and the outcome of these chronic obstructive respiratory diseases, is growing. Likewise, the role of pathogenic and colonizing microorganisms of the respiratory tract in the development and manifestation of asthma and COPD is increasingly appreciated. However, their role remains poorly understood with respect to the underlying mechanisms. Common bacteria and viruses causing respiratory infections and exacerbations of chronic obstructive respiratory diseases have also been implicated to affect the local neuro-immune crosstalk. In this review, we provide an overview of previously described neuro-immune interactions in asthma, COPD, and respiratory infections that support the hypothesis of a neuro-immunological component in the interplay between chronic obstructive respiratory diseases, respiratory infections, and respiratory microbial colonization. Full article
(This article belongs to the Special Issue Neuroinflammatory Processes in Organ Homeostasis and Disease)
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