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Molecular Approach to Obstructive Sleep Apnea Syndrome: Precise Diagnosis and Targeted Treatment

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (23 July 2021) | Viewed by 4214

Special Issue Editors


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Guest Editor
Department of Head-Neck Surgery, Otolaryngology, Head-Neck and Oral Surgery Unit, Morgagni Pierantoni Hospital, Azienda USL della Romagna, Forlì, Italy
Interests: OSA; TORS; palate surgery; DISE; snoring; sleep disorders; salivary glands; sialoendoscopy
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
1. Department of Head-Neck Surgery, Otolaryngology, Head-Neck and Oral Surgery Unit, Morgagni Pierantoni Hospital, Azienda USL della Romagna, Forlì, Italy
2. Unit of Otolaryngology, University of Ferrara, Ferrara, Italy
Interests: OSA; TORS; palate surgery; DISE; snoring; sleep disorders; salivary glands; sialoendoscopy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Obstructive Sleep Apnea syndrome (OSAS) is a frequent condition estimated in 5%-12% of the adult population and its impact on cardiovascular risk seems to be consistent.

The consequences of obstructive sleep apnea (OSA) are largely mediated by chronic intermittent hypoxia and sleep fragmentation. The primary molecular domains affected are sympathetic activity, oxidative stress and inflammation. Other affected domains include adipokines, adhesion molecules and molecules that respond to endoplasmic reticulum stress.

During the last decade significant steps towards a precision medicine approach have been taken, also in the field of sleep disorder management.

The aim of this special issue is to collect Molecular Approach on diagnostic advancements and targeted therapies outcomes of OSAS and other sleep disorders.

In particular, we are going to consider papers regarding:

Novel aspects of CPAP treatment and interventions to improve CPAP adherence;

Emerging pharmacotherapy of OSA;

Evaluation of OSA-related biomarkers

Pathogenetic mechanisms and consequences of OSA

Chronic Intermittent Hypoxia

Sleep Fragmentation

Innovative therapies for OSA treatment

We are certain of your active collaboration to create an interesting Special Issue that will help physicians to identify the most appropriate therapeutic choice for patients affected by sleep disorders

Dr. Giovanni Cammaroto
Prof. Claudio Vicini
Guest Editors

Manuscript Submission Information

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Keywords

  • sleep disorders
  • obstructive sleep apnea
  • sleepiness health
  • CPAP
  • quality of life
  • prevention

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Published Papers (1 paper)

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Review

12 pages, 1059 KiB  
Review
Epigenetic Alterations in Pediatric Sleep Apnea
by Emily Catherine Cheung, Matthew Wyatt Kay and Kathryn Jaques Schunke
Int. J. Mol. Sci. 2021, 22(17), 9523; https://doi.org/10.3390/ijms22179523 - 1 Sep 2021
Cited by 3 | Viewed by 3732
Abstract
Pediatric obstructive sleep apnea has significant negative effects on health and behavior in childhood including depression, failure to thrive, neurocognitive impairment, and behavioral issues. It is strongly associated with an increased risk for chronic adult disease such as obesity and diabetes, accelerated atherosclerosis, [...] Read more.
Pediatric obstructive sleep apnea has significant negative effects on health and behavior in childhood including depression, failure to thrive, neurocognitive impairment, and behavioral issues. It is strongly associated with an increased risk for chronic adult disease such as obesity and diabetes, accelerated atherosclerosis, and endothelial dysfunction. Accumulating evidence suggests that adult-onset non-communicable diseases may originate from early life through a process by which an insult applied at a critical developmental window causes long-term effects on the structure or function of an organism. In recent years, there has been increased interest in the role of epigenetic mechanisms in the pathogenesis of adult disease susceptibility. Epigenetic mechanisms that influence adaptive variability include histone modifications, non-coding RNAs, and DNA methylation. This review will highlight what is currently known about the phenotypic associations of epigenetic modifications in pediatric obstructive sleep apnea and will emphasize the importance of epigenetic changes as both modulators of chronic disease and potential therapeutic targets. Full article
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